Creon and Xgeva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Creon (pancrelipase (amylase;lipase;protease)) and Xgeva (denosumab). Common drug interactions include diarrhoea among females and neuroendocrine carcinoma metastatic among males.

The phase IV clinical study analyzes what interactions people have when they take Creon and Xgeva. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,489 Creon users. Check the latest studies of Creon.

What is Xgeva?

Xgeva has active ingredients of denosumab. It is often used in breast cancer. eHealthMe is studying from 37,717 Xgeva users. Check the latest studies of Xgeva.

On Aug, 09, 2026

23 people who take Creon and Xgeva together, and have interactions are studied.

What are the common drug interactions of Creon and Xgeva, by gender? *:

female:

Diarrhoea
Fatigue (feeling of tiredness)
Dyspnoea (difficult or laboured respiration)
Anxiety
Arthralgia (joint pain)
Gallbladder disorder
Hot flush (sudden feelings of heat)
Presyncope
Red blood cell count decreased
White blood cell count decreased

male:

Neuroendocrine carcinoma metastatic (cancer tumour that arise from cells of the endocrine (hormonal) and nervous systems and spreads to other part)
Groin pain
Autoimmune myocarditis (inflammation of the heart muscle by immune system disorder)
Back pain
Blood pressure decreased
Constipation
Faecaloma (hard mass of fecal matter)
Fatigue (feeling of tiredness)
General physical health deterioration (weak health status)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)

What are the common drug interactions of Creon and Xgeva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Neuroendocrine carcinoma metastatic (cancer tumour that arise from cells of the endocrine (hormonal) and nervous systems and spreads to other part)
Groin pain
Infection
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Osteonecrosis of jaw (death of bone of jaw)
Tooth extraction
Anaemia (lack of blood)
Arthralgia (joint pain)
Autoimmune myocarditis (inflammation of the heart muscle by immune system disorder)
Back pain

60+:

Diarrhoea
Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Asthenia (weakness)
Blood cholesterol increased
Blood pressure increased
Gait disturbance
General physical health deterioration (weak health status)
Malignant neoplasm progression (cancer tumour came back)
Nasopharyngitis (inflammation of the nasopharynx)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 6 people, 26.09%
Stress And Anxiety: 3 people, 13.04%
Neuroendocrine Tumor: 3 people, 13.04%
Nausea (feeling of having an urge to vomit): 3 people, 13.04%
Lung Cancer - Non-Small Cell (lung cancer): 3 people, 13.04%
Diarrhea: 3 people, 13.04%
Tumor: 2 people, 8.70%
Pancreatic Carcinoma (pancreatic cancer): 2 people, 8.70%
Lactose Intolerance (inability to digest lactose): 2 people, 8.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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