Cylert and Seroquel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cylert (pemoline) and Seroquel (quetiapine fumarate). Common drug interactions include diabetes mellitus among females and abnormal behaviour among males.

The phase IV clinical study analyzes what interactions people have when they take Cylert and Seroquel. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Cylert?

Cylert has active ingredients of pemoline. eHealthMe is studying from 785 Cylert users. Check the latest studies of Cylert.

What is Seroquel?

Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 120,285 Seroquel users. Check the latest studies of Seroquel.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

15 people who take Cylert and Seroquel together, and have interactions are studied.

What are the common drug interactions of Cylert and Seroquel, by gender? *:

female:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Cardiac failure
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hyperglycaemia (high blood sugar)
Retinal disorder (disease of retina)
Blood triglycerides increased
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Obesity (having too much body fat)
Alanine aminotransferase increased
Aspartate aminotransferase increased

male:

Abnormal behaviour
Chest discomfort
Abdominal pain upper
Activities of daily living impaired
Aggression
Agitation (state of anxiety or nervous excitement)
Anger
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Brain injury
Chest pain

What are the common drug interactions of Cylert and Seroquel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abnormal behaviour
Chest discomfort
Essential hypertension (primary hypertension)
Hallucination, visual (seeing things that aren't there)
Impulse-control disorder
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Schizophrenia, paranoid type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect)
Type 1 diabetes mellitus
Weight increased

20-29:

Drug addiction
Self-injurious ideation

30-39:

Blood cholesterol increased
Blood triglycerides increased
Drug intolerance (drug sensitivity)
Headache (pain in head)
Hyperlipidaemia (presence of excess lipids in the blood)
Pancreatitis (inflammation of pancreas)
Type 2 diabetes mellitus
Alanine aminotransferase increased
Aspartate aminotransferase increased
Gamma-glutamyltransferase increased

40-49:

Blood triglycerides increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Obesity (having too much body fat)
Nephrolithiasis (calculi in the kidneys)

50-59:

Cardiac failure
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hyperglycaemia (high blood sugar)
Retinal disorder (disease of retina)

60+:

n/a

What are the existing conditions these people have? *

Depression: 7 people, 46.67%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 33.33%
Asthma: 3 people, 20.00%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 20.00%
Insomnia (sleeplessness): 3 people, 20.00%
Stress And Anxiety: 2 people, 13.33%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 6.67%
Disturbance In Attention: 1 person, 6.67%
Autism (a mental condition, present from early childhood, characterized by difficulty in communicating and forming relationships with other people and in using language and abstract concepts): 1 person, 6.67%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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