Cymbalta and Sublocade drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cymbalta (duloxetine hydrochloride) and Sublocade (buprenorphine). Common drug interactions include drug withdrawal syndrome among females and drug withdrawal syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Cymbalta and Sublocade. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,973 Cymbalta users. Check the latest studies of Cymbalta.

What is Sublocade?

Sublocade has active ingredients of buprenorphine. eHealthMe is studying from 4,530 Sublocade users. Check the latest studies of Sublocade.

On Jul, 18, 2026

18 people who take Cymbalta and Sublocade together, and have interactions are studied.

Cymbalta and Sublocade drug interactions.

What are the common drug interactions of Cymbalta and Sublocade, by gender? *:

female:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Injection site pain
Maternal exposure during pregnancy (use of substance during pregnancy)
Drug dependence
Injection site erythema (redness at injection site)
Muscle spasms (muscle contraction)
Abdominal mass (localized enlargement or swelling in the human abdomen)
Abdominal pain
Blood lactate dehydrogenase increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

male:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Injection site erythema (redness at injection site)
Tooth infection
Yawning (simultaneous inhalation of air and stretching of the eardrums, followed by exhalation of breath)
Drug dependence
Injection site irritation
Injection site pruritus (severe itching at injection site)
Joint swelling
Oedema peripheral (superficial swelling)
Rash macular (small, flat red spots)

What are the common drug interactions of Cymbalta and Sublocade, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Drug dependence
Injection site erythema (redness at injection site)
Injection site irritation
Injection site pruritus (severe itching at injection site)
Joint swelling
Oedema peripheral (superficial swelling)
Rash macular (small, flat red spots)
Maternal exposure during pregnancy (use of substance during pregnancy)
Injection site pain

40-49:

Insomnia (sleeplessness)
Muscle spasms (muscle contraction)
Thirst
Tinnitus (a ringing in the ears)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Diarrhoea
Drug dependence
Fatigue (feeling of tiredness)
Injection site cellulitis (injection site inflammation)
Injection site erythema (redness at injection site)

50-59:

Injection site pain
Injection site erythema (redness at injection site)

60+:

n/a

What are the existing conditions these people have? *

Drug Dependence: 10 people, 55.56%
Stress And Anxiety: 4 people, 22.22%
Pain: 2 people, 11.11%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 2 people, 11.11%
Sleep Disorder: 1 person, 5.56%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 5.56%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.56%
Insomnia (sleeplessness): 1 person, 5.56%
High Blood Pressure: 1 person, 5.56%
Drowsiness: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Cymbalta and Sublocade?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously