Cytomel and Vivactil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cytomel (liothyronine sodium) and Vivactil (protriptyline hydrochloride). Common drug interactions include bladder prolapse among females and brain damage among males.

The phase IV clinical study analyzes what interactions people have when they take Cytomel and Vivactil. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Cytomel?

Cytomel has active ingredients of liothyronine sodium. It is often used in hypothyroidism. eHealthMe is studying from 7,595 Cytomel users. Check the latest studies of Cytomel.

What is Vivactil?

Vivactil has active ingredients of protriptyline hydrochloride. eHealthMe is studying from 386 Vivactil users. Check the latest studies of Vivactil.

On Jul, 13, 2026

34 people who take Cytomel and Vivactil together, and have interactions are studied.

What are the common drug interactions of Cytomel and Vivactil, by gender? *:

female:

Bladder prolapse (bulging of one or more of the pelvic organs into the vagina)
Insomnia (sleeplessness)
Pruritus (severe itching of the skin)
Road traffic accident
Weight decreased
Weight increased
Constipation
Alopecia (absence of hair from areas of the body)
Onychoclasis (breaking of the nails)
Pain in extremity

male:

Brain damage
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Disturbance in attention
Encephalopathy (functioning of the brain is affected by some agent or condition)
Flat affect (absence of emotional response to a situation)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Psychomotor retardation (motor mental retardation)
Red blood cells csf positive
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

What are the common drug interactions of Cytomel and Vivactil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Brain damage
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Akinesia (loss of control of voluntary muscle movements)
Cerebral haemorrhage (bleeding within the brain)
Confusional state
Csf glucose decreased
Csf protein increased
Csf white blood cell count increased
Depression

30-39:

n/a

40-49:

Nausea (feeling of having an urge to vomit)
Suicidal ideation
Suicide attempt
Upper limb fracture

50-59:

n/a

60+:

Hypersensitivity
Laryngitis (inflammation of the larynx)
Skin wrinkling (wrinkle on skin)
Tooth disorder (tooth disease)
Viral upper respiratory tract infection
Anaemia (lack of blood)
Constipation
Drug ineffective
Dyspepsia (indigestion)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 29 people, 85.29%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 29 people, 85.29%
Depression: 11 people, 32.35%
High Blood Pressure: 7 people, 20.59%
Stress And Anxiety: 3 people, 8.82%
Rickets (softening of bones): 3 people, 8.82%
Pain: 3 people, 8.82%
Nausea (feeling of having an urge to vomit): 3 people, 8.82%
Migraine Without Aura (headache without neurological problems): 3 people, 8.82%
Migraine (headache): 3 people, 8.82%

* Approximation only. Some reports may have incomplete information.

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