Cytomel and Vytorin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cytomel (liothyronine sodium) and Vytorin (ezetimibe; simvastatin). Common drug interactions include nervous system disorder among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Cytomel and Vytorin. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Cytomel?

Cytomel has active ingredients of liothyronine sodium. It is often used in hypothyroidism. eHealthMe is studying from 7,596 Cytomel users. Check the latest studies of Cytomel.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

31 people who take Cytomel and Vytorin together, and have interactions are studied.

What are the common drug interactions of Cytomel and Vytorin, by gender? *:

female:

Nervous system disorder (a general class of medical conditions affecting the nervous system)
Pain
Pain in extremity
Weight increased
Dizziness
Drug ineffective
Fibromyalgia (a long-term condition which causes pain all over the body)
Osteoporosis (bones weak and more likely to break)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

male:

Depression
Throat cancer
Dysphagia (a condition in which swallowing is difficult or painful)
Fistula (an abnormal connection or passageway between two)
Radiation injury (injuries are caused by radiation)

What are the common drug interactions of Cytomel and Vytorin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dyspnoea (difficult or laboured respiration)
Arterial thrombosis (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system)
Blood uric acid increased
Burning sensation
Chest pain
Chronic inflammatory demyelinating polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Depression
Drug ineffective
Erythromelalgia (episodes of pain, redness, and swelling in various parts of the body)

50-59:

Pneumonia
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Anxiety
Arthralgia (joint pain)
Aspartate aminotransferase increased
Back pain
Bone pain
Cardiovascular disorder (heart diseases)
Chest pain

60+:

Nausea (feeling of having an urge to vomit)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Alopecia (absence of hair from areas of the body)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety disorder
Arrhythmia supraventricular (irregular heartbeat supraventricular origin)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 22.58%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 12.90%
Pain: 4 people, 12.90%
High Blood Pressure: 4 people, 12.90%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 9.68%
Depression: 3 people, 9.68%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 9.68%
Bipolar Disorder (mood disorder): 3 people, 9.68%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 9.68%
Type 2 Diabetes: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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