Dapsone and Busulfan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dapsone (dapsone) and Busulfan (busulfan). Common drug interactions include respiratory failure among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Dapsone and Busulfan. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Dapsone?

Dapsone has active ingredients of dapsone. It is often used in dermatitis herpetiformis. eHealthMe is studying from 11,732 Dapsone users. Check the latest studies of Dapsone.

What is Busulfan?

Busulfan has active ingredients of busulfan. eHealthMe is studying from 14,527 Busulfan users. Check the latest studies of Busulfan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

48 people who take Dapsone and Busulfan together, and have interactions are studied.

What are the common drug interactions of Dapsone and Busulfan, by gender? *:

female:

Respiratory failure (inadequate gas exchange by the respiratory system)
Liver disorder (liver diseases)
Pulmonary haemorrhage (acute bleeding from the lung)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Venoocclusive disease (small veins in the liver are obstructed)
Bacterial sepsis
Renal impairment (severely reduced kidney function)
Pain
Dizziness
Febrile neutropenia (fever with reduced white blood cells)

male:

Hypotension (abnormally low blood pressure)
Respiratory failure (inadequate gas exchange by the respiratory system)
Infection reactivation
Lung consolidation (a condition whereby the lung tissues solidify because of the accumulation of solid and liquid material in the air spaces)
Mobility decreased (ability to move is reduced)
Pyrexia (fever)
Cerebral toxoplasmosis (parasitic disease of brain caused by the protozoan toxoplasma gondii)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Hyperglycaemia (high blood sugar)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

What are the common drug interactions of Dapsone and Busulfan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Idiopathic pneumonia syndrome (pneumonia-like symptoms)
Mucosal inflammation (infection of mucous membrane)
Cytomegalovirus infection
Liver disorder (liver diseases)
Pulmonary haemorrhage (acute bleeding from the lung)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Respiratory failure (inadequate gas exchange by the respiratory system)
Venoocclusive disease (small veins in the liver are obstructed)
Bacterial sepsis
Renal impairment (severely reduced kidney function)

10-19:

n/a

20-29:

Chills (felling of cold)
Pyrexia (fever)
Rash
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

30-39:

Venoocclusive liver disease (small veins in the liver are obstructed)
Bacterial sepsis
Bk virus infection
Blood creatinine increased
Cystitis viral (inflammation of the wall of the bladder by virus)
Cytomegalovirus infection
Decreased appetite
Disease progression
Hyperglycaemia (high blood sugar)
Hyperkalaemia (damage to or disease of the kidney)

40-49:

Abdominal pain
Adenovirus infection
Bacterial sepsis
Cytomegalovirus infection
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Idiopathic pneumonia syndrome (pneumonia-like symptoms)
Leukaemia recurrent (repeat cancer of bone marrow or blood cells)
Liver disorder (liver diseases)

50-59:

Diffuse alveolar damage (common manifestation of drug-induced lung injury)
Leukoencephalopathy (disease of the white matter in the brain)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Encephalitis (inflammation of the brain)
Infection reactivation
Lung consolidation (a condition whereby the lung tissues solidify because of the accumulation of solid and liquid material in the air spaces)
Mobility decreased (ability to move is reduced)
Pyrexia (fever)
Cerebral toxoplasmosis (parasitic disease of brain caused by the protozoan toxoplasma gondii)

60+:

Respiratory failure (inadequate gas exchange by the respiratory system)
Dizziness
Idiopathic pneumonia syndrome (pneumonia-like symptoms)
Liver disorder (liver diseases)
Pulmonary haemorrhage (acute bleeding from the lung)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Renal failure (kidney dysfunction)
Venoocclusive disease (small veins in the liver are obstructed)
Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)

What are the existing conditions these people have? *

Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 20 people, 41.67%
Bone Marrow Failure: 10 people, 20.83%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 8 people, 16.67%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 5 people, 10.42%
Graft Versus Host Disease In Lung (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the lung): 4 people, 8.33%
Bone Marrow Conditioning Regimen: 4 people, 8.33%
Neuropathy Peripheral (surface nerve damage): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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