Daptomycin and Keflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Daptomycin (daptomycin) and Keflex (cephalexin). Common drug interactions include drug resistance among females and hepatotoxicity among males.

The phase IV clinical study analyzes what interactions people have when they take Daptomycin and Keflex. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Daptomycin?

Daptomycin has active ingredients of daptomycin. eHealthMe is studying from 7,879 Daptomycin users. Check the latest studies of Daptomycin.

What is Keflex?

Keflex has active ingredients of cephalexin. It is often used in infection. eHealthMe is studying from 15,844 Keflex users. Check the latest studies of Keflex.

On Jul, 30, 2026

21 people who take Daptomycin and Keflex together, and have interactions are studied.

Daptomycin and Keflex drug interactions.

What are the common drug interactions of Daptomycin and Keflex, by gender? *:

female:

Drug resistance (reduction in effectiveness of a drug)
Dry mouth
Dysmenorrhoea (painful menstruation)
Dyspepsia (indigestion)
Dyspnoea exertional (breathlessness or shortness of breath)
Enterococcal infection
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Epstein-barr viraemia
Exposure to communicable disease
Eye disorder

male:

Hepatotoxicity (chemical-driven liver damage)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Anion gap increased
Anxiety
Aspartate aminotransferase increased
Asthenia (weakness)
Back disorder
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)

What are the common drug interactions of Daptomycin and Keflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Idiopathic intracranial hypertension (elevated cerebrospinal fluid pressure of unknown cause)
Infectious pleural effusion (infectious fluid in the lung)
Postoperative wound infection
Staphylococcal infection (an infection with staphylococcus bacteria)
Chest pain
Headache (pain in head)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Meningitis viral (viral inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Rectal haemorrhage (bleeding from anus)

30-39:

Device related infection
Wound dehiscence (a surgical incision reopens either internally or externally)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Injury
Pulmonary embolism (blockage of the main artery of the lung)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)

40-49:

Asthma

50-59:

Dry mouth
Dysmenorrhoea (painful menstruation)
Emotional distress
Enterococcal infection
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Epstein-barr viraemia
Exposure to communicable disease
Fear
Frequent bowel movements
Gastritis (inflammation of stomach)

60+:

Hepatotoxicity (chemical-driven liver damage)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Anaemia (lack of blood)
Anal abscess
Anaphylactic reaction (serious allergic reaction)
Anion gap increased
Aspartate aminotransferase increased
Back disorder
Blood pressure increased
Catheter site erythema (redness of skin at catheter site)

What are the existing conditions these people have? *

Pain: 8 people, 38.10%
Urinary Tract Infection: 7 people, 33.33%
Stress And Anxiety: 7 people, 33.33%
Constipation: 7 people, 33.33%
Nausea (feeling of having an urge to vomit): 7 people, 33.33%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 6 people, 28.57%
Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries)): 6 people, 28.57%
Hypokalemia (low potassium): 6 people, 28.57%
Hypoparathyroidism (inadequate secretion of parathyroid hormone resulting in abnormally low levels of calcium in the blood): 6 people, 28.57%
Headache (pain in head): 6 people, 28.57%

* Approximation only. Some reports may have incomplete information.

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