Darunavir and Sofosbuvir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Darunavir (darunavir) and Sofosbuvir (sofosbuvir). Common drug interactions include supraventricular tachycardia among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Darunavir and Sofosbuvir. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Darunavir?

Darunavir has active ingredients of darunavir. eHealthMe is studying from 6,483 Darunavir users. Check the latest studies of Darunavir.

What is Sofosbuvir?

Sofosbuvir has active ingredients of sofosbuvir. eHealthMe is studying from 9,194 Sofosbuvir users. Check the latest studies of Sofosbuvir.

On Jul, 11, 2026

26 people who take Darunavir and Sofosbuvir together, and have interactions are studied.

Darunavir and Sofosbuvir drug interactions.

What are the common drug interactions of Darunavir and Sofosbuvir, by gender? *:

female:

Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Alanine aminotransferase increased
Anaemia (lack of blood)
Aspartate aminotransferase increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chills (felling of cold)
Cough
Diarrhoea
Glycosuria (excretion of glucose into the urine)
Hyperbilirubinaemia (excess of bilirubin in the blood)

male:

Anaemia (lack of blood)
Fatigue (feeling of tiredness)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Factor viii inhibition (suppression of factor viii)
Hepatic failure (liver failure)
Hepatic neoplasm (liver tumour)
Leukaemia (blood or bone marrow cancer)
Overdose
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)
Thrombosis mesenteric vessel (blood clot in mesenteric vein)

What are the common drug interactions of Darunavir and Sofosbuvir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Glycosuria (excretion of glucose into the urine)
Hypokalaemia (low potassium)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Proteinuria (presence of protein in the urine)
Renal failure (kidney dysfunction)

40-49:

Anaemia (lack of blood)
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Leukopenia (less number of white blood cells in blood)
Thrombocytopenia (decrease of platelets in blood)
Weight decreased
Factor viii inhibition (suppression of factor viii)

50-59:

Alanine aminotransferase increased
Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Aspartate aminotransferase increased
Disease progression
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Hepatic neoplasm (liver tumour)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Immune system disorder
Immunodeficiency

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chills (felling of cold)
Cough
Diarrhoea
Hypophagia (reduced food intake)
Productive cough
Pyrexia (fever)

What are the existing conditions these people have? *

Hiv Infection: 12 people, 46.15%
Hepatitis C: 11 people, 42.31%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 3 people, 11.54%
Dyslipidaemia (abnormal amount of lipids): 3 people, 11.54%
Rickets (softening of bones): 2 people, 7.69%
Depression: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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