Dayquil and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dayquil (acetaminophen; dextromethorphan; pseudoephedrine) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include wound infection among females and blood bicarbonate increased among males.

The phase IV clinical study analyzes what interactions people have when they take Dayquil and Macrobid. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Dayquil?

Dayquil has active ingredients of acetaminophen; dextromethorphan; pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 1,815 Dayquil users. Check the latest studies of Dayquil.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

23 people who take Dayquil and Macrobid together, and have interactions are studied.

What are the common drug interactions of Dayquil and Macrobid, by gender? *:

female:

Wound infection
Sinusitis (inflammation of sinus)
Completed suicide (act of taking one's own life)
Hypoglycaemic coma (coma due to deficiency of glucose in the bloodstream)
Pain
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting
Abdominal distension
Acute hepatic failure
Allergic sinusitis

male:

Blood bicarbonate increased
Breath sounds
Hypospadias (an abnormal condition in males in which the urethra opens on the under surface of the penis)
Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Injury
Intercostal retraction (inward movement of the muscles between the ribs as a result of reduced pressure in the chest cavity)
Lung disorder (lung disease)
Nasal flaring (nostrils widen while a person is breathing)
Oxygen saturation decreased
Pneumonia primary atypical (primary atypical pneumonia which were probably caused by mycoplasma pneumoniae)

What are the common drug interactions of Dayquil and Macrobid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Completed suicide (act of taking one's own life)
Hypoglycaemic coma (coma due to deficiency of glucose in the bloodstream)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Pain
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pulmonary embolism (blockage of the main artery of the lung)
Sepsis (a severe blood infection that can lead to organ failure and death)
Somnolence (a state of near-sleep, a strong desire for sleep)
Vomiting

50-59:

Abdominal distension
Decreased appetite
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness
Drug hypersensitivity
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Fall
Fatigue (feeling of tiredness)
Foot fracture
Gastrointestinal infection (infection of stomach and intestine)

60+:

Allergic sinusitis

What are the existing conditions these people have? *

Depression: 9 people, 39.13%
Multiple Allergies (allergy to multiple agents): 8 people, 34.78%
Immunodeficiency Common Variable: 5 people, 21.74%
Sinusitis (inflammation of sinus): 3 people, 13.04%
Nasopharyngitis (inflammation of the nasopharynx): 3 people, 13.04%
Type 1 Diabetes: 2 people, 8.70%
Pharyngitis (inflammation of the pharynx, causing a sore throat): 2 people, 8.70%
Pain: 2 people, 8.70%
Multiple Myeloma (cancer of the plasma cells): 2 people, 8.70%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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