Deferasirox and Neupogen drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Deferasirox (deferasirox) and Neupogen (filgrastim). Common drug interactions include acute myeloid leukaemia among females and basal cell carcinoma among males.
The phase IV clinical study analyzes what interactions people have when they take Deferasirox and Neupogen. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.
What is Deferasirox?
Deferasirox has active ingredients of deferasirox. eHealthMe is studying from 2,641 Deferasirox users. Check the latest studies of Deferasirox.
What is Neupogen?
Neupogen has active ingredients of filgrastim. It is often used in agranulocytosis. eHealthMe is studying from 23,898 Neupogen users. Check the latest studies of Neupogen.
26 people who take Deferasirox and Neupogen together, and have interactions are studied.

What are the common drug interactions of Deferasirox and Neupogen, by gender? *:
female:
- Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
- White blood cell count decreased
- Anaemia (lack of blood)
- Bk virus infection
- Cytomegalovirus infection
- Haemochromatosis (body to absorb more iron than usual from food)
- Duodenal ulcer haemorrhage (bleeding duodenal ulcer)
- Sepsis (a severe blood infection that can lead to organ failure and death)
- Subdural haematoma (blood collects between the skull and the surface of the brain)
- Cardiac failure congestive
male:
- Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
- Blood lactate dehydrogenase increased
- Drug ineffective
- Dyspnoea (difficult or laboured respiration)
- Haematuria (presence of blood in urine)
- Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
- Hypertension (high blood pressure)
- Local swelling (swelling at the site of some application of substance or injury)
- Oxygen saturation decreased
- Haemoglobin decreased
What are the common drug interactions of Deferasirox and Neupogen, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
- Adenovirus infection
- Bk virus infection
- Blastocystis infection
- Cytomegalovirus infection
- Haemochromatosis (body to absorb more iron than usual from food)
- Sepsis (a severe blood infection that can lead to organ failure and death)
10-19:
- Bk virus infection
- Cystitis haemorrhagic (blood in the urine and painful voiding)
- Cytomegalovirus infection
- Haemochromatosis (body to absorb more iron than usual from food)
20-29:
n/a
30-39:
n/a
40-49:
- Contusion (a type of hematoma of tissue in which capillaries)
- Death
50-59:
- Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
- Cardiac failure congestive
- Fungal infection
- Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
- Staphylococcal infection (an infection with staphylococcus bacteria)
- Cerebral infarction (less blood supply to brain resulting tissue damage)
- Cerebrovascular disorder (disease of brain)
60+:
- Haemoglobin decreased
- Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
- Duodenal ulcer haemorrhage (bleeding duodenal ulcer)
- Subdural haematoma (blood collects between the skull and the surface of the brain)
- Lung infection
- Pleural effusion (water on the lungs)
- Serum sickness-like reaction
- Abdominal pain upper
- Antipsychotic drug level increased
- Anxiety
What are the existing conditions these people have? *
- Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 6 people, 23.08%
- Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 5 people, 19.23%
- Haemosiderosis (general increase in tissue iron stores without associated tissue damage): 4 people, 15.38%
- Bone Marrow Conditioning Regimen: 4 people, 15.38%
- Aplastic Anemia: 3 people, 11.54%
- Tremor (trembling or shaking movements in one or more parts of your body): 2 people, 7.69%
- Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 2 people, 7.69%
- Post Herpetic Neuralgia (neuralgia caused by the varicella zoster virus): 2 people, 7.69%
- Oedema (fluid collection in tissue): 2 people, 7.69%
- Nephrogenic Anaemia (anaemia due to kidney disease): 2 people, 7.69%
* Approximation only. Some reports may have incomplete information.
Do you take Deferasirox and Neupogen?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Deferasirox (2,641 reports)
- Neupogen (23,898 reports)
Browse all drug interactions of Deferasirox and Neupogen:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Deferasirox:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Neupogen:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Deferasirox and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Neupogen and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Díaz-García JD, Gallegos-Villalobos A, Gonzalez-Espinoza L, Sanchez-Ni?o MD, Villarrubia J, Ortiz A, "Deferasirox nephrotoxicity [mdash] the knowns and unknowns", Nature reviews nephrology, 2014 Oct .
- Riva A, "Comment on: A record number of fatalities in many categories of patients treated with deferasirox: loopholes in regulatory and marketing procedures undermine patient safety and misguide public funds?", Expert opinion on drug safety, 2013 Sep .
- Riva A, "Deferasirox's toxicity", The Lancet, 2013 Jul .
- Kontoghiorghes GJ, "Turning a blind eye to deferasirox's toxicity?", The Lancet, 2013 Apr .
- Kontoghiorghes GJ, "A record number of fatalities in many categories of patients treated with deferasirox: loopholes in regulatory and marketing procedures undermine patient safety and misguide public funds?", Taylor & Francis, 2013 Jan .
- Díaz-García JD, Gallegos-Villalobos A, Gonzalez-Espinoza L, Sanchez-Ni?o MD, Villarrubia J, Ortiz A, "Deferasirox nephrotoxicity [mdash] the knowns and unknowns", Nature reviews nephrology, 2014 Oct .
- Riva A, "Comment on: A record number of fatalities in many categories of patients treated with deferasirox: loopholes in regulatory and marketing procedures undermine patient safety and misguide public funds?", Expert opinion on drug safety, 2013 Sep .
- Riva A, "Deferasirox's toxicity", The Lancet, 2013 Jul .
- Kontoghiorghes GJ, "Turning a blind eye to deferasirox's toxicity?", The Lancet, 2013 Apr .
- Kontoghiorghes GJ, "A record number of fatalities in many categories of patients treated with deferasirox: loopholes in regulatory and marketing procedures undermine patient safety and misguide public funds?", Taylor & Francis, 2013 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on deferasirox and filgrastim (the active ingredients of Deferasirox and Neupogen, respectively), and Deferasirox and Neupogen (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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