Delsym and Phenergan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Delsym (dextromethorphan polistirex) and Phenergan (promethazine hydrochloride). Common drug interactions include haemodynamic instability among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Delsym and Phenergan. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Delsym?

Delsym has active ingredients of dextromethorphan polistirex. It is often used in cough. eHealthMe is studying from 5,033 Delsym users. Check the latest studies of Delsym.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

On Jul, 18, 2026

14 people who take Delsym and Phenergan together, and have interactions are studied.

What are the common drug interactions of Delsym and Phenergan, by gender? *:

female:

Haemodynamic instability (disturbances in the blood movement in our body)
Haemorrhage (bleeding)
Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)
White blood cell count increased
Abdominal pain upper
Rhinorrhoea (watery mucus discharge from the nose)
Vertigo
Weight increased
Abdominal pain
Blindness

male:

Dyspnoea (difficult or laboured respiration)
Hypoxia (low oxygen in tissues)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Pulmonary embolism (blockage of the main artery of the lung)
Sepsis (a severe blood infection that can lead to organ failure and death)
Interstitial lung disease
Blood alkaline phosphatase increased
General physical health deterioration (weak health status)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atypical mycobacterium test positive

What are the common drug interactions of Delsym and Phenergan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Abdominal pain upper
Cholecystitis chronic (long lasting infection of gallbladder)
Depression
Gallbladder cholesterolosis (accumulation and deposition of cholesterol inside of the)
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Hepatic steatosis (fatty liver disease)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
White blood cell count increased

40-49:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pitting oedema (skin discoloration)
Pleural effusion (water on the lungs)
Postmenopausal symptoms
Protein total increased
Pulmonary oedema (fluid accumulation in the lungs)
Tricuspid valve incompetence (inefficient heart valve)
Vestibular disorder (disorders of the body's balance (vestibular) system in the inner ear)
Viral infection
Visual acuity reduced (reduced clearness of vision)

50-59:

n/a

60+:

Dyspnoea (difficult or laboured respiration)
Hypoxia (low oxygen in tissues)
Atypical mycobacterium test positive
Blood albumin decreased
Blood calcium increased
Blood phosphorus increased
Blood pressure systolic increased
Cardiac failure congestive
Cerebral haemorrhage (bleeding within the brain)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 4 people, 28.57%
Pain: 2 people, 14.29%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 14.29%
Weight Decreased: 1 person, 7.14%
Back Pain: 1 person, 7.14%
Blood Potassium Decreased: 1 person, 7.14%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 7.14%
Depression: 1 person, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.14%
Heart Rate Increased: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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