Demadex and Hydramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Demadex (torsemide) and Hydramine (diphenhydramine hydrochloride). Common drug interactions include dyspnoea exertional among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Demadex and Hydramine. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Demadex?

Demadex has active ingredients of torsemide. It is often used in heart failure. eHealthMe is studying from 5,358 Demadex users. Check the latest studies of Demadex.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

On Aug, 09, 2026

54 people who take Demadex and Hydramine together, and have interactions are studied.

Demadex and Hydramine drug interactions.

What are the common drug interactions of Demadex and Hydramine, by gender? *:

female:

Dyspnoea exertional (breathlessness or shortness of breath)
Fluid retention (an abnormal accumulation of fluid in the blood)
Gait disturbance
Influenza like illness
Injection site pain
Localised oedema (fluid retention in a particular part of the body)
Muscle spasms (muscle contraction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oedema peripheral (superficial swelling)
Otorrhoea (discharge from the ear)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Cardiac failure congestive
Cellulitis (infection under the skin)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Constipation
Death
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

What are the common drug interactions of Demadex and Hydramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hypersensitivity
Pruritus generalised (generalized itching)
Rash erythematous (redness of the skin)

40-49:

Hypotension (abnormally low blood pressure)
Pleural effusion (water on the lungs)
Acute respiratory failure
Ascites (accumulation of fluid in the abdominal cavity)
Cellulitis (infection under the skin)
Dizziness
Dyspnoea (difficult or laboured respiration)
Fluid overload (too much fluid in the blood)
Gastric ulcer (stomach ulcer)
Malaise (a feeling of general discomfort or uneasiness)

50-59:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Thrombosis (formation of a blood clot inside a blood vessel)
Ventricular hypertrophy (enlargement of ventricles (lower chambers) in the heart)
Cardiovascular disorder (heart diseases)
Death
Stroke in evolution (unstable stage in stroke syndrome in which the blockage is present but the syndrome has not progressed to the stage of completed stroke)
Renal cyst (kidney cyst)
Renal impairment (severely reduced kidney function)
Staphylococcal infection (an infection with staphylococcus bacteria)
Angina pectoris (chest pain due to ischemia of the heart muscle)

60+:

Urinary tract infection
Dehydration (dryness resulting from the removal of water)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Pruritus (severe itching of the skin)
Stroke in evolution (unstable stage in stroke syndrome in which the blockage is present but the syndrome has not progressed to the stage of completed stroke)
Blood pressure increased
Blood sodium decreased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Diarrhoea
Ear infection

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 9 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 14.81%
Immunodeficiency Common Variable: 7 people, 12.96%
Immunodeficiency: 7 people, 12.96%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 11.11%
Oedema (fluid collection in tissue): 6 people, 11.11%
Constipation: 6 people, 11.11%
Nausea (feeling of having an urge to vomit): 5 people, 9.26%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 4 people, 7.41%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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