Demerol and Mefoxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Demerol (meperidine hydrochloride) and Mefoxin (cefoxitin sodium). Common drug interactions include dysphagia among females and international normalised ratio increased among males.

The phase IV clinical study analyzes what interactions people have when they take Demerol and Mefoxin. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Demerol?

Demerol has active ingredients of meperidine hydrochloride. It is often used in pain. eHealthMe is studying from 12,706 Demerol users. Check the latest studies of Demerol.

What is Mefoxin?

Mefoxin has active ingredients of cefoxitin sodium. eHealthMe is studying from 280 Mefoxin users. Check the latest studies of Mefoxin.

On Jul, 10, 2026

39 people who take Demerol and Mefoxin together, and have interactions are studied.

What are the common drug interactions of Demerol and Mefoxin, by gender? *:

female:

Dysphagia (a condition in which swallowing is difficult or painful)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Platelet count increased
Cor pulmonale chronic (long lasting enlargement of the right ventricle of the heart)
Gastroduodenitis (an inflammation of the mucous membrane of the stomach and duodenum)
Hypoaesthesia (reduced sense of touch or sensation)
Uterine enlargement
Device failure
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Scab (a hard coating on the skin formed during the wound healing)

male:

International normalised ratio increased
Abdominal pain
Blood creatinine increased
Blood urea increased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Diarrhoea
Fatigue (feeling of tiredness)
Haemolytic anaemia (anaemia due to haemolysis)
Hypotension (abnormally low blood pressure)
Irritable bowel syndrome

What are the common drug interactions of Demerol and Mefoxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Anxiety
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Emotional distress
Headache (pain in head)
Injury
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Renal failure acute (rapid kidney dysfunction)

30-39:

Abdominal pain
Colitis ulcerative (inflammation of colon with ulcer)
Diarrhoea
Intestinal perforation (complete penetration of the wall of the intestine)
Toxic dilatation of colon (enlargement of colon due to toxin)
Activated partial thromboplastin time prolonged
Anxiety
Ascites (accumulation of fluid in the abdominal cavity)
Blood fibrinogen increased
Blood pressure ambulatory decreased

40-49:

Abdominal distension
Abdominal pain
Device dislocation
Dysmenorrhoea (painful menstruation)
Fatigue (feeling of tiredness)
Lymphocyte count decreased
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Uterine haemorrhage (uterine bleeding)
Haemangioma of skin (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)

50-59:

Platelet count increased
Cor pulmonale chronic (long lasting enlargement of the right ventricle of the heart)
Gastroduodenitis (an inflammation of the mucous membrane of the stomach and duodenum)
Uterine enlargement
Device failure
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Scab (a hard coating on the skin formed during the wound healing)
Tooth extraction
Hypoaesthesia (reduced sense of touch or sensation)
Sensory loss (senses loss)

60+:

Abdominal infection
Enterocutaneous fistula
Hypoaesthesia (reduced sense of touch or sensation)
Peripheral coldness
Skin discolouration (change of skin colour)
Thrombocythaemia (an increased number of platelets in the circulating blood)
Anaemia (lack of blood)
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Oedema upper limb (swelling of arm)

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 20 people, 51.28%
Osteoporosis (bones weak and more likely to break): 20 people, 51.28%
Thrombocytopenia (decrease of platelets in blood): 11 people, 28.21%
Depression: 6 people, 15.38%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 7.69%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 7.69%
Migraine Without Aura (headache without neurological problems): 3 people, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.13%
Constipation: 2 people, 5.13%
Dehydration (dryness resulting from the removal of water): 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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