Depakene and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depakene (valproic acid) and Melatonin (melatonin). Common drug interactions include death among females and seizure among males.

The phase IV clinical study analyzes what interactions people have when they take Depakene and Melatonin. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,776 Depakene users. Check the latest studies of Depakene.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Jul, 26, 2026

30 people who take Depakene and Melatonin together, and have interactions are studied.

Depakene and Melatonin drug interactions.

What are the common drug interactions of Depakene and Melatonin, by gender? *:

female:

Death
Pneumonia
Abdominal distension
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Influenza
Respiratory failure (inadequate gas exchange by the respiratory system)
Urinary tract infection
Apnoea (suspension of external breathing)
Atelectasis (partial or complete collapse of the lung)
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)

male:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Blood albumin increased
Blood glucose increased
Blood pressure increased
Cerebral disorder (brain disease)
Crying
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Drug ineffective
Erythema (redness of the skin)

What are the common drug interactions of Depakene and Melatonin, by age (0-1 to 60+)? *:

0-1:

Decreased appetite
Gait disturbance
Irritability
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Speech disorder

2-9:

Angioedema (rapid swelling of the dermis)
Abnormal behaviour
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
Atonic seizures (minor type of seizure)
Blood albumin increased
Blood glucose increased
Cerebral disorder (brain disease)
Crying
Drug hypersensitivity
Drug ineffective

10-19:

Pneumonia
Abdominal distension
Death
Influenza
Respiratory failure (inadequate gas exchange by the respiratory system)
Urinary tract infection
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Respiratory tract infection

20-29:

n/a

30-39:

n/a

40-49:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Type 2 diabetes mellitus

50-59:

n/a

60+:

Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)
Confusional state
Drug abuse
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Vision blurred

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 12 people, 40.00%
Constipation: 8 people, 26.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 16.67%
Dermatitis Diaper (diaper rash is a common form of inflamed skin): 5 people, 16.67%
Pain: 4 people, 13.33%
Wheezing (a high-pitched whistling sound made while you breath): 3 people, 10.00%
Precocious Puberty: 3 people, 10.00%
Sleep Disorder: 2 people, 6.67%
Skin Infection: 2 people, 6.67%
Respiration Abnormal (abnormal breathing process): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Depakene and Melatonin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously