Depakene and Unasyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depakene (valproic acid) and Unasyn (ampicillin sodium; sulbactam sodium). Common drug interactions include carpal tunnel syndrome among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Depakene and Unasyn. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,776 Depakene users. Check the latest studies of Depakene.

What is Unasyn?

Unasyn has active ingredients of ampicillin sodium; sulbactam sodium. eHealthMe is studying from 4,474 Unasyn users. Check the latest studies of Unasyn.

On Jul, 05, 2026

47 people who take Depakene and Unasyn together, and have interactions are studied.

What are the common drug interactions of Depakene and Unasyn, by gender? *:

female:

Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cellulitis (infection under the skin)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Claustrophobia (fear of having no escape and being closed in small spaces)
Clavicle fracture
Colitis ulcerative (inflammation of colon with ulcer)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))

male:

Pneumonia
Haemorrhagic diathesis (bleeding tendency)
Erythropenia (a deficiency in the number of red blood cells)
Gastric hypomotility (less movement of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperchlorhydria (gastric acid levels are higher in stomach)
Interstitial lung disease
Leukopenia (less number of white blood cells in blood)
Stress cardiomyopathy (stress-induced chronic disease of the heart muscle)
Urinary tract infection

What are the common drug interactions of Depakene and Unasyn, by age (0-1 to 60+)? *:

0-1:

Constipation
Gastric hypomotility (less movement of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperchlorhydria (gastric acid levels are higher in stomach)
Urinary tract infection
Vesicoureteric reflux (urine flows from the bladder, back up the ureter, and back into the kidneys)

2-9:

n/a

10-19:

n/a

20-29:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug level decreased

30-39:

Disease progression
Hydrocephalus (water on the brain)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Inflammation
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Osteomyelitis (infection of bone)
Platelet count decreased
Radiation injury (injuries are caused by radiation)
Septic shock (shock due to blood infection)
Type 2 diabetes mellitus

40-49:

Abdominal pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Depression
Drug level decreased
Enteritis (inflammation of the small intestine)
Epstein-barr virus antigen positive
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Granulocytopenia (lack of granulocyte)
Immunosuppressant drug level increased
Lymphadenopathy (disease or enlargement of lymph nodes)

50-59:

Thrombocytopenia (decrease of platelets in blood)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Erythropenia (a deficiency in the number of red blood cells)
Leukopenia (less number of white blood cells in blood)
Stress cardiomyopathy (stress-induced chronic disease of the heart muscle)
Altered state of consciousness (altered state of mind)
Anaplastic astrocytoma (tumour of the glial (supportive) tissue of the brain)
Blood pressure increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

60+:

Pneumonia
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Interstitial lung disease
Arteriosclerosis (thickening and hardening of arteries)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Neutropenia (an abnormally low number of neutrophils)
Respiratory failure (inadequate gas exchange by the respiratory system)
Cerebral infarction (less blood supply to brain resulting tissue damage)

What are the existing conditions these people have? *

Pneumonia: 9 people, 19.15%
Insomnia (sleeplessness): 6 people, 12.77%
Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 5 people, 10.64%
Diabetes: 5 people, 10.64%
Staphylococcal Infection (an infection with staphylococcus bacteria): 4 people, 8.51%
Aortic Valve Atresia (congenital malformation of the aortic valve): 4 people, 8.51%
Cerebral Infarction (less blood supply to brain resulting tissue damage): 4 people, 8.51%
Constipation: 4 people, 8.51%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.38%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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