Depakote er and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depakote er (divalproex sodium) and Melatonin (melatonin). Common drug interactions include drug ineffective among females and aggression among males.

The phase IV clinical study analyzes what interactions people have when they take Depakote er and Melatonin. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Depakote er?

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 6,042 Depakote er users. Check the latest studies of Depakote er.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Jul, 15, 2026

44 people who take Depakote er and Melatonin together, and have interactions are studied.

Depakote er and Melatonin drug interactions.

What are the common drug interactions of Depakote Er and Melatonin, by gender? *:

female:

Drug ineffective
Therapeutic response unexpected
Bradycardia (abnormally slow heart action)
Fall
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Anxiety
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Stress
Arthralgia (joint pain)
Colitis (inflammation of colon)

male:

Aggression
Anxiety
Gait disturbance
Hospitalisation
Hyperhidrosis (abnormally increased sweating)
Renal failure (kidney dysfunction)
Vomiting
Hypersomnia (excessive daytime sleepiness (eds))
Lethargy (tiredness)
Abdominal pain upper

What are the common drug interactions of Depakote Er and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Depression
Hypersomnia (excessive daytime sleepiness (eds))
Lethargy (tiredness)
Abnormal behaviour
Aggression
Agitation (state of anxiety or nervous excitement)
Chorea (abnormal involuntary movement disorder)
Dental caries
Drug ineffective
Fall

20-29:

Nausea (feeling of having an urge to vomit)
Diarrhoea
Gait disturbance
Hospitalisation
Hyperhidrosis (abnormally increased sweating)
Vomiting
Abdominal pain upper
Depression
Hyperammonaemia
Tremor (trembling or shaking movements in one or more parts of your body)

30-39:

Aggression
Anxiety
Drug level increased
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Drug ineffective
Hypogeusia (reduced ability to taste things (to taste sweet, sour, bitter, or salty substances))

40-49:

Arthralgia (joint pain)
Drug ineffective
Fall
Pain
Therapeutic response unexpected

50-59:

Anxiety
Chronic kidney disease
Colitis (inflammation of colon)
Depression
Drug ineffective
Drug level increased
Hypokinesia (decreased bodily movement)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site swelling
Mania (a state of abnormally elevated or irritable mood)

60+:

Diarrhoea
Arthralgia (joint pain)
Heart rate increased
Lymphocyte count decreased
Palpitations (feelings or sensations that your heart is pounding or racing)
Platelet count decreased
Suicidal ideation
Tremor (trembling or shaking movements in one or more parts of your body)
Vision blurred
Asthenia (weakness)

What are the existing conditions these people have? *

Stress And Anxiety: 5 people, 11.36%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 11.36%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 11.36%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 11.36%
Sleep Disorder: 4 people, 9.09%
Pain: 4 people, 9.09%
Depression: 4 people, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.82%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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