Descovy and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Descovy (emtricitabine; tenofovir alafenamide fumarate) and Melatonin (melatonin). Common drug interactions include iron deficiency anaemia among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Descovy and Melatonin. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Descovy?

Descovy has active ingredients of emtricitabine; tenofovir alafenamide fumarate. It is often used in hiv infection. eHealthMe is studying from 14,260 Descovy users. Check the latest studies of Descovy.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,213 Melatonin users. Check the latest studies of Melatonin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

48 people who take Descovy and Melatonin together, and have interactions are studied.

Descovy and Melatonin drug interactions.

What are the common drug interactions of Descovy and Melatonin, by gender? *:

female:

Iron deficiency anaemia
Limb injury
Muscular weakness (muscle weakness)
Oedema (fluid collection in tissue)
Osteonecrosis (death of bone)
Quality of life decreased
Rales (an abnormal respiratory sound characterized by fine crackles)
Renal failure (kidney dysfunction)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tremor (trembling or shaking movements in one or more parts of your body)

male:

Pain
Emotional distress
Fatigue (feeling of tiredness)
Asthenia (weakness)
Back pain
Gait disturbance
Nephropathy (damage to or disease of a kidney)
Skeletal injury (bone and supporting muscle injury)
Abdominal distension
Anaemia (lack of blood)

What are the common drug interactions of Descovy and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hypersensitivity

30-39:

Upper limb fracture
Anxiety
Emotional distress
Osteoporosis (bones weak and more likely to break)
Pain
Arthralgia (joint pain)
Bone density decreased
Depression
Fracture
Fractured sacrum

40-49:

Anxiety
Emotional distress
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chronic kidney disease
Osteoporosis (bones weak and more likely to break)
Renal impairment (severely reduced kidney function)
Bone density decreased
Renal failure (kidney dysfunction)
Ankle fracture

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Chronic kidney disease
Depression
Osteoporosis (bones weak and more likely to break)
Renal impairment (severely reduced kidney function)
Bone density decreased
Osteopenia (a condition where bone mineral density is lower than normal)

60+:

Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Back pain
Death
Depression
Gingival disorder (gum disease)
Infection
Myalgia (muscle pain)
Osteoporosis (bones weak and more likely to break)
Proteinuria (presence of protein in the urine)

* Approximation only. Some reports may have incomplete information.

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