Desogen and Ultram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Desogen (desogestrel; ethinyl estradiol) and Ultram (tramadol hydrochloride). Common drug interactions include deep vein thrombosis among females.

The phase IV clinical study analyzes what interactions people have when they take Desogen and Ultram. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Desogen?

Desogen has active ingredients of desogestrel; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 664 Desogen users. Check the latest studies of Desogen.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

15 people who take Desogen and Ultram together, and have interactions are studied.

What are the common drug interactions of Desogen and Ultram, by gender? *:

female:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Dilatation ventricular
Pupil fixed
Anxiety
Cardiomegaly (increased size of heart than normal)
Haematocrit
Myositis (inflammation of the muscles)
Nausea (feeling of having an urge to vomit)

male:

n/a

What are the common drug interactions of Desogen and Ultram, by age (0-1 to 60+)? *:

0-1:

Blood cholesterol increased
Blood triglycerides increased
Hyperprolactinaemia (abnormally high levels of prolactin in the blood)
Leiomyoma (a noncancerous (benign) tumour made up mostly of smooth muscle cells)
Obesity (having too much body fat)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Patellofemoral pain syndrome (pain in the front of the knee)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Type 2 diabetes mellitus

2-9:

n/a

10-19:

Gastritis (inflammation of stomach)

20-29:

Grand mal convulsion (a type of generalized seizure that affects the entire brain)

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Dilatation ventricular
Pupil fixed
Anxiety
Cardiomegaly (increased size of heart than normal)
Haematocrit
Myositis (inflammation of the muscles)
Nausea (feeling of having an urge to vomit)

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Dysfunctional Uterine Bleeding (Dub): 3 people, 20.00%
Ovarian Disorder (disease of ovary): 2 people, 13.33%
Mood Swings (an extreme or rapid change in mood): 2 people, 13.33%
Polycystic Ovary Disease (cysts in the ovaries that occurs when the follicle stops developing): 1 person, 6.67%
Juvenile Arthritis (arthritis-related condition that develops in children or teenagers): 1 person, 6.67%
Headache (pain in head): 1 person, 6.67%
Diabetes: 1 person, 6.67%
Depression: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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