Desyrel and Adcirca drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Desyrel (trazodone hydrochloride) and Adcirca (tadalafil). Common drug interactions include hypoxia among females and weight increased among males.

The phase IV clinical study analyzes what interactions people have when they take Desyrel and Adcirca. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Desyrel?

Desyrel has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 6,595 Desyrel users. Check the latest studies of Desyrel.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

On Jul, 10, 2026

23 people who take Desyrel and Adcirca together, and have interactions are studied.

What are the common drug interactions of Desyrel and Adcirca, by gender? *:

female:

Hypoxia (low oxygen in tissues)
Dizziness
Dyspnoea (difficult or laboured respiration)
Blood glucose fluctuation
Chills (felling of cold)
Death
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Pneumonia
Anxiety

male:

Weight increased
Abscess neck (neck abscesses)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Brain natriuretic peptide increased
Chronic kidney disease
Cough
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Endocarditis (inflammation in heart muscle)
Fatigue (feeling of tiredness)

What are the common drug interactions of Desyrel and Adcirca, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abscess neck (neck abscesses)
Renal impairment (severely reduced kidney function)
Weight increased
Infusion site erythema (reddening of the skin at infusion site)
Infusion site inflammation
Infusion site pain
Infusion site swelling
Infusion site warmth
Infusion site infection
Infusion site induration

40-49:

Death
Hypoxia (low oxygen in tissues)
Pneumonia
Cough
Hepatitis (inflammation of the liver)
Hepatopulmonary syndrome (syndrome of shortness of breath and hypoxemia (low oxygen levels in the blood of the arteries) in the lungs of patients with liver disease)

50-59:

Continuous positive airway pressure
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hypoaesthesia (reduced sense of touch or sensation)
Laceration (tearing of soft body tissue)
Small intestinal obstruction (blockage in small intestine)

60+:

Blood glucose fluctuation
Chills (felling of cold)
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Oedema peripheral (superficial swelling)
Respiratory syncytial virus infection (viral disease of respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)
Stent placement
Viral infection
Dizziness

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 15 people, 65.22%
Injection Site Pain: 6 people, 26.09%
Asthma: 3 people, 13.04%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 8.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.70%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 8.70%
Depression: 2 people, 8.70%
Constipation: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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