Depo-provera and Botox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depo-provera (medroxyprogesterone acetate) and Botox (botulinum toxin type a). Common drug interactions include abdominal pain upper among females.

The phase IV clinical study analyzes what interactions people have when they take Depo-provera and Botox. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Depo-provera?

Depo-provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 17,093 Depo-provera users. Check the latest studies of Depo-provera.

What is Botox?

Botox has active ingredients of botulinum toxin type a. It is often used in migraine. eHealthMe is studying from 70,513 Botox users. Check the latest studies of Botox.



On Jul, 10, 2026

46 people who take Depo-provera and Botox together, and have interactions are studied.

Depo-provera and Botox drug interactions.

What are the common drug interactions of Depo-Provera and Botox, by gender? *:

female:

  1. Abdominal pain upper
  2. Muscle spasms (muscle contraction)
  3. Vision blurred
  4. Visual impairment
  5. Activities of daily living impaired
  6. Anger
  7. Balance disorder
  8. Chromatopsia (visual defect in which colourless objects appear to be tinged with colour)
  9. Communication disorder (speech and language disorder)
  10. Contusion (a type of hematoma of tissue in which capillaries)

male:

n/a

What are the common drug interactions of Depo-Provera and Botox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Headache (pain in head)
  2. Injection site pain
  3. Muscular weakness (muscle weakness)
  4. Nausea (feeling of having an urge to vomit)
  5. Tremor (trembling or shaking movements in one or more parts of your body)
  6. Vomiting
  7. Blindness transient (sudden loss of vision)
  8. Breast enlargement
  9. Breast tenderness
  10. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

30-39:

  1. Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
  2. Anxiety
  3. Abdominal pain upper
  4. Activities of daily living impaired
  5. Anger
  6. Balance disorder
  7. Chromatopsia (visual defect in which colourless objects appear to be tinged with colour)
  8. Communication disorder (speech and language disorder)
  9. Constipation
  10. Contusion (a type of hematoma of tissue in which capillaries)

40-49:

  1. Dry mouth
  2. Muscle spasms (muscle contraction)
  3. Pain
  4. Sleep terror (felling of terror in sleep)
  5. Thirst
  6. Tongue dry
  7. Urinary tract infection
  8. Weight increased
  9. Urinary retention (the inability to completely or partially empty the bladder)
  10. Abdominal pain upper

50-59:

  1. Headache (pain in head)

60+:

  1. Drug ineffective
  2. Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
  3. Streptococcal infection
  4. Respiratory tract infection

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 23.91%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 17.39%
  3. Asthma: 7 people, 15.22%
  4. Hypersensitivity: 6 people, 13.04%
  5. Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 13.04%
  6. Nausea (feeling of having an urge to vomit): 6 people, 13.04%
  7. Stress And Anxiety: 5 people, 10.87%
  8. Muscle Spasms (muscle contraction): 5 people, 10.87%
  9. Nausea And Vomiting: 5 people, 10.87%
  10. Pain: 5 people, 10.87%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Depo-provera and Botox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Depo-provera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Botox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Depo-provera and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Botox and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on medroxyprogesterone acetate and botulinum toxin type a (the active ingredients of Depo-provera and Botox, respectively), and Depo-provera and Botox (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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