Desyrel and Aredia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Desyrel (trazodone hydrochloride) and Aredia (pamidronate disodium). Common drug interactions include metastases to bone among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Desyrel and Aredia. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Desyrel?

Desyrel has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 6,595 Desyrel users. Check the latest studies of Desyrel.

What is Aredia?

Aredia has active ingredients of pamidronate disodium. It is often used in breast cancer. eHealthMe is studying from 15,365 Aredia users. Check the latest studies of Aredia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

27 people who take Desyrel and Aredia together, and have interactions are studied.

What are the common drug interactions of Desyrel and Aredia, by gender? *:

female:

Metastases to bone (cancer spreads to bone)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Intervertebral disc protrusion (spinal disc protrusion)
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back))
Lacunar infarction (a type of stroke)
Neoplasm progression (growth of tumour)
Hypokalaemia (low potassium)
Pleural effusion (water on the lungs)
Dyspnoea (difficult or laboured respiration)

male:

Anxiety
Asthenia (weakness)
Emotional distress
Hypoaesthesia (reduced sense of touch or sensation)
Hypokalaemia (low potassium)
Hypoxia (low oxygen in tissues)
Infection
Leukopenia (less number of white blood cells in blood)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

What are the common drug interactions of Desyrel and Aredia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Infection
Pain
Spinal osteoarthritis (joint cartilage loss in spine)
Confusional state
Dyspnoea (difficult or laboured respiration)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Metastases to bone (cancer spreads to bone)
Nodule (a growth of abnormal tissue)
Balance disorder
Fatigue (feeling of tiredness)

60+:

Anxiety
Back pain
Spinal osteoarthritis (joint cartilage loss in spine)
Tooth fracture
Toothache (tooth pain)
Bone disorder
Osteonecrosis of jaw (death of bone of jaw)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Actinomycosis (infection that causes sores, or abscesses)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 14 people, 51.85%
Stress And Anxiety: 13 people, 48.15%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 48.15%
Bone Pain: 13 people, 48.15%
Breast Cancer Metastatic: 7 people, 25.93%
Multiple Myeloma (cancer of the plasma cells): 3 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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