Roxanol and Centrum silver drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Roxanol (morphine sulfate) and Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e). Common drug interactions include arthropathy among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Roxanol and Centrum silver. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Roxanol?

Roxanol has active ingredients of morphine sulfate. eHealthMe is studying from 807 Roxanol users. Check the latest studies of Roxanol.

What is Centrum silver?

Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,997 Centrum silver users. Check the latest studies of Centrum silver.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Sep, 03, 2026

18 people who take Roxanol and Centrum silver together, and have interactions are studied.

Roxanol and Centrum silver drug interactions.

What are the common drug interactions of Roxanol and Centrum Silver, by gender? *:

female:

  1. Arthropathy
  2. Asthenia (weakness)
  3. Balance disorder
  4. Beta 2 microglobulin increased
  5. Bone cyst
  6. Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
  7. Bone loss
  8. Breast cancer
  9. Breast cancer female
  10. Burning sensation

male:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Intervertebral disc degeneration (spinal disc degeneration)
  4. Pleural fibrosis (formation of fibrous tissue in lung)
  5. Arthralgia (joint pain)
  6. Dyspnoea (difficult or laboured respiration)
  7. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  8. Osteonecrosis of jaw (death of bone of jaw)
  9. Asthenia (weakness)
  10. Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)

What are the common drug interactions of Roxanol and Centrum Silver, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Aortic valve incompetence
  2. Arteriosclerosis (thickening and hardening of arteries)
  3. Arthralgia (joint pain)
  4. Arthropathy
  5. Asthenia (weakness)
  6. Balance disorder
  7. Beta 2 microglobulin increased
  8. Bone cyst
  9. Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
  10. Bone loss

50-59:

  1. Injury
  2. Myelitis transverse (a neurological condition consisting of an inflammatory process of the spinal cord)
  3. Pain
  4. Intervertebral disc degeneration (spinal disc degeneration)
  5. Pleural fibrosis (formation of fibrous tissue in lung)
  6. Arthralgia (joint pain)
  7. Osteonecrosis of jaw (death of bone of jaw)
  8. Asthenia (weakness)
  9. Dyspnoea (difficult or laboured respiration)
  10. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

60+:

  1. Angioedema (rapid swelling of the dermis)
  2. Drug ineffective
  3. Hepatitis c

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 13 people, 72.22%
  2. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 16.67%
  3. Stress And Anxiety: 2 people, 11.11%
  4. Skin Ulcer: 1 person, 5.56%
  5. Pain: 1 person, 5.56%
  6. Nausea (feeling of having an urge to vomit): 1 person, 5.56%
  7. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.56%
  8. Hepatitis C: 1 person, 5.56%
  9. Headache (pain in head): 1 person, 5.56%
  10. Fever: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Roxanol and Centrum silver?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Roxanol and Centrum silver:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Roxanol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Centrum silver:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Roxanol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Centrum silver and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate and ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Roxanol and Centrum silver, respectively), and Roxanol and Centrum silver (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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