Desyrel and Estraderm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Desyrel (trazodone hydrochloride) and Estraderm (estradiol). Common drug interactions include headache among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Desyrel and Estraderm. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Desyrel?

Desyrel has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 6,595 Desyrel users. Check the latest studies of Desyrel.

What is Estraderm?

Estraderm has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 3,441 Estraderm users. Check the latest studies of Estraderm.

On Aug, 05, 2026

25 people who take Desyrel and Estraderm together, and have interactions are studied.

Desyrel and Estraderm drug interactions.

What are the common drug interactions of Desyrel and Estraderm, by gender? *:

female:

Headache (pain in head)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain in extremity
Cough
Dyspnoea exertional (breathlessness or shortness of breath)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Nausea (feeling of having an urge to vomit)
Anxiety
Atelectasis (partial or complete collapse of the lung)
Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)

male:

Abdominal pain upper
Abscess (pus)
Bronchopleural fistula
Bunion (a painful swelling on the first joint of the big toe)
Cancer pain
Cardiomegaly (increased size of heart than normal)
Cerebrovascular disorder (disease of brain)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Chest pain
Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)

What are the common drug interactions of Desyrel and Estraderm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Back pain
Bone pain
Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)
Breast cancer
Breast cyst
Breast pain
Breast tenderness

50-59:

Abdominal pain upper
Abscess (pus)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Atelectasis (partial or complete collapse of the lung)
Blood urea nitrogen/creatinine ratio increased
Bronchopleural fistula
Cardiomegaly (increased size of heart than normal)
Cerebrovascular disorder (disease of brain)

60+:

Vomiting
Weight decreased

What are the existing conditions these people have? *

Bone Density Abnormal: 8 people, 32.00%
Menopause (end of monthly cycles in women): 7 people, 28.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 28.00%
Osteoporosis (bones weak and more likely to break): 5 people, 20.00%

* Approximation only. Some reports may have incomplete information.

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