Diamox and B12 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diamox (acetazolamide) and B12 (cobalamin). Common drug interactions include malignant melanoma among females and vision blurred among males.

The phase IV clinical study analyzes what interactions people have when they take Diamox and B12. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Diamox?

Diamox has active ingredients of acetazolamide. It is often used in pseudotumor cerebri. eHealthMe is studying from 4,711 Diamox users. Check the latest studies of Diamox.

What is B12?

B12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 121,894 B12 users. Check the latest studies of B12.



On Jul, 08, 2026

90 people who take Diamox and B12 together, and have interactions are studied.

Diamox and B12 drug interactions.

What are the common drug interactions of Diamox and B12, by gender? *:

female:

  1. Malignant melanoma (skin cancer rises from melancytes)
  2. Meibomianitis (any condition that increases the thickness of the oily secretions of the meibomian glands will allow excess oils to accumulate on the edges of the lids)
  3. White blood cell count decreased
  4. Drug ineffective
  5. Activities of daily living impaired
  6. Back disorder
  7. Cellulitis (infection under the skin)
  8. Cough
  9. Gait disturbance
  10. Nausea (feeling of having an urge to vomit)

male:

  1. Vision blurred
  2. Dyspnoea (difficult or laboured respiration)
  3. Pruritus (severe itching of the skin)
  4. Urticaria (rash of round, red welts on the skin that itch intensely)
  5. Flushing (the warm, red condition of human skin)
  6. Hyperhidrosis (abnormally increased sweating)
  7. Hypotension (abnormally low blood pressure)
  8. Intraocular pressure increased
  9. Malaise (a feeling of general discomfort or uneasiness)
  10. Migraine (headache)

What are the common drug interactions of Diamox and B12, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Influenza
  2. Pneumonia

20-29:

  1. Back disorder
  2. Dizziness
  3. Headache (pain in head)
  4. Injection site pain
  5. Injection site urticaria (rash of round, red welts on the skin at injection site)
  6. Limb discomfort (discomfort in leg)
  7. Nausea (feeling of having an urge to vomit)
  8. Constipation
  9. Decreased appetite
  10. Diplopia (double vision)

30-39:

  1. Cellulitis (infection under the skin)
  2. Loss of consciousness
  3. Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
  4. Syncope (loss of consciousness with an inability to maintain postural tone)

40-49:

  1. Anxiety
  2. Depression
  3. Suicidal ideation
  4. Abasia (inability to walk)
  5. Activities of daily living impaired
  6. Alopecia (absence of hair from areas of the body)
  7. Anaemia (lack of blood)
  8. Ascites (accumulation of fluid in the abdominal cavity)
  9. Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
  10. Burning sensation

50-59:

  1. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  2. Ataxia (loss of full control of bodily movements)
  3. Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
  4. Cerebral atrophy (decrement in size of brain)
  5. Cerebral infarction (less blood supply to brain resulting tissue damage)
  6. Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)
  7. Confusional state
  8. Dysarthria (speech disorder)
  9. Encephalomalacia (localized softening of the brain substance, due to haemorrhage or inflammation)
  10. Encephalopathy (functioning of the brain is affected by some agent or condition)

60+:

  1. Pruritus (severe itching of the skin)
  2. Rash
  3. Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
  4. Asthenia (weakness)
  5. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  6. Chills (felling of cold)
  7. Constipation
  8. Contusion (a type of hematoma of tissue in which capillaries)
  9. Diarrhoea
  10. Dysphagia (a condition in which swallowing is difficult or painful)

What are the existing conditions these people have? *

  1. Dizziness: 38 people, 42.22%
  2. Pain: 16 people, 17.78%
  3. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 11.11%
  4. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 7.78%
  5. Depression: 6 people, 6.67%
  6. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Diamox and B12?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Diamox and B12:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Diamox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of B12:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Diamox and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between B12 and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on acetazolamide and cobalamin (the active ingredients of Diamox and B12, respectively), and Diamox and B12 (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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