Diazepam and Nicotinamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diazepam (diazepam) and Nicotinamide (niacin and niacinamide (vitamin b3)). Common drug interactions include grip strength decreased among females and cardio-respiratory arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Diazepam and Nicotinamide. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Diazepam?

Diazepam has active ingredients of diazepam. It is often used in stress and anxiety. eHealthMe is studying from 108,384 Diazepam users. Check the latest studies of Diazepam.

What is Nicotinamide?

Nicotinamide has active ingredients of niacin and niacinamide (vitamin b3). eHealthMe is studying from 1,992 Nicotinamide users. Check the latest studies of Nicotinamide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

33 people who take Diazepam and Nicotinamide together, and have interactions are studied.

Diazepam and Nicotinamide drug interactions.

What are the common drug interactions of Diazepam and Nicotinamide, by gender? *:

female:

Grip strength decreased
Hypertension (high blood pressure)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Body height decreased
Cerebral atrophy (decrement in size of brain)
Drug intolerance (drug sensitivity)
Dyskinesia (abnormality or impairment of voluntary movement)
Foot fracture
Infusion site oedema (swelling from excessive accumulation of watery fluid from infusion site)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)

male:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Electrocardiogram qt prolonged
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Renal disorder (kidney disease)
Hepatocellular injury (liver injury)
Hypoprothrombinaemia (blood disorder in which a deficiency of prothrombin (factor ii) results in impaired blood clotting)
Acute hepatic failure
Acute respiratory failure
Coma (state of unconsciousness lasting more than six hours)
Oxygen saturation decreased

What are the common drug interactions of Diazepam and Nicotinamide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug intolerance (drug sensitivity)
Dyskinesia (abnormality or impairment of voluntary movement)
Infusion site oedema (swelling from excessive accumulation of watery fluid from infusion site)
Tremor (trembling or shaking movements in one or more parts of your body)
Death
Septic shock (shock due to blood infection)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

20-29:

Apnoea (suspension of external breathing)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Circulatory collapse
Completed suicide (act of taking one's own life)
Diabetes insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function)
Dizziness
Hypotension (abnormally low blood pressure)
Methaemoglobinaemia (a disorder characterized by the presence of a higher than normal level of methemoglobin in blood)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Unresponsive to stimuli

30-39:

n/a

40-49:

n/a

50-59:

Hepatocellular injury (liver injury)
Hypoprothrombinaemia (blood disorder in which a deficiency of prothrombin (factor ii) results in impaired blood clotting)

60+:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Electrocardiogram qt prolonged
Foot fracture
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Memory impairment
Osteoporosis (bones weak and more likely to break)
Oxygen saturation decreased
Pneumonia
Spinal cord disorder (disease of spinal cord)
Embolic stroke (stroke due to obstruction due to an embolus)

What are the existing conditions these people have? *

Lung Disorder (lung disease): 7 people, 21.21%
Bipolar Disorder (mood disorder): 7 people, 21.21%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 4 people, 12.12%
Pain: 4 people, 12.12%
Hypersensitivity: 4 people, 12.12%
Sedation: 2 people, 6.06%
Oedema (fluid collection in tissue): 2 people, 6.06%
Muscle Spasms (muscle contraction): 2 people, 6.06%
Mitochondrial Myopathy (the muscle fibres do not function due to damage of mitochondria): 2 people, 6.06%
Menopause (end of monthly cycles in women): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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