Differin and Levaquin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Differin (adapalene) and Levaquin (levofloxacin). Common drug interactions include muscle tightness among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Differin and Levaquin. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,740 Differin users. Check the latest studies of Differin.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

On Jul, 11, 2026

23 people who take Differin and Levaquin together, and have interactions are studied.

Differin and Levaquin drug interactions.

What are the common drug interactions of Differin and Levaquin, by gender? *:

female:

Muscle tightness
Oesophageal achalasia (difficulty swallowing, food sticking in the oesophagus)
Oesophageal stenosis (narrowing of oesophagus)
Pain in extremity
Pharyngolaryngeal pain
Pleural effusion (water on the lungs)
Pain
Myalgia (muscle pain)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)

male:

Anaemia (lack of blood)
Anxiety
Post cholecystectomy syndrome
Blood uric acid increased
Cholecystitis chronic (long lasting infection of gallbladder)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Gallbladder disorder
Gallbladder pain
Haemorrhoidal haemorrhage (bleeding from the haemorrhoids)
Injury

What are the common drug interactions of Differin and Levaquin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Gallbladder disorder
Pain
Cholecystitis (infection of gallbladder)
Cholecystitis acute (rapid infection of gallbladder)
Emotional distress
Injury

30-39:

Emotional distress
Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Pain
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Pulmonary infarction (death of a small area of lung)
Abasia (inability to walk)
Anaemia (lack of blood)

40-49:

Furuncle (infection of the hair follicle)
Headache (pain in head)
Hepatotoxicity (chemical-driven liver damage)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Irritable bowel syndrome
Laryngeal oedema (swelling of larynx)
Leukopenia (less number of white blood cells in blood)
Muscle tightness
Oesophageal achalasia (difficulty swallowing, food sticking in the oesophagus)
Oesophageal stenosis (narrowing of oesophagus)

50-59:

Alopecia (absence of hair from areas of the body)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Breast pain
Cough
Dyspnoea exertional (breathlessness or shortness of breath)
Emotional distress
Exercise tolerance decreased
Gait disturbance

60+:

Cholecystitis chronic (long lasting infection of gallbladder)
Gallbladder disorder
Pain
Polyp
Post cholecystectomy syndrome
Anaemia (lack of blood)
Anxiety
Aortic dissection rupture
Blood uric acid increased
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

What are the existing conditions these people have? *

Pain: 8 people, 34.78%
Irritable Bowel Syndrome: 8 people, 34.78%
Laryngitis (inflammation of the larynx): 7 people, 30.43%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 30.43%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 7 people, 30.43%
Birth Control: 3 people, 13.04%
Migraine (headache): 2 people, 8.70%
Depression: 2 people, 8.70%
Cough: 2 people, 8.70%
Breast Cancer Female: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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