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Differin and Monodox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Differin (adapalene) and Monodox (doxycycline). Common drug interactions include colitis among females.

The phase IV clinical study analyzes what interactions people have when they take Differin and Monodox. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,740 Differin users. Check the latest studies of Differin.

What is Monodox?

Monodox has active ingredients of doxycycline. It is often used in acne. eHealthMe is studying from 388 Monodox users. Check the latest studies of Monodox.

On Jul, 13, 2026

12 people who take Differin and Monodox together, and have interactions are studied.

Differin and Monodox drug interactions.

What are the common drug interactions of Differin and Monodox, by gender? *:

female:

  1. Colitis (inflammation of colon)
  2. Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
  3. Back pain
  4. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
  5. Lipids increased (excess lipid in body)
  6. Viral infection
  7. Xerosis (abnormal dryness of the skin or mucus membranes)
  8. Photopsia (presence of perceived flashes of light)
  9. Blood cholesterol increased
  10. Ear pain

male:

n/a

What are the common drug interactions of Differin and Monodox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
  2. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
  3. Haemorrhoids (a swollen vein or group of veins in the region of the anus)
  4. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
  5. Inflammatory bowel disease
  6. Intervertebral disc degeneration (spinal disc degeneration)
  7. Irritable bowel syndrome
  8. Lipids increased (excess lipid in body)
  9. Photopsia (presence of perceived flashes of light)
  10. Proctitis (inflammation of the rectum and anus)

20-29:

n/a

30-39:

n/a

40-49:

  1. Abdominal pain
  2. Haematocrit decreased
  3. Haemoglobin decreased
  4. Incision site pain
  5. Drug ineffective
  6. Hysterectomy
  7. White blood cell count increased

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Psoriasis (immune-mediated disease that affects the skin): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Differin and Monodox?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Differin and Monodox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Differin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Monodox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Differin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Monodox and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on adapalene and doxycycline (the active ingredients of Differin and Monodox, respectively), and Differin and Monodox (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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