Zyrtec and Florinef drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyrtec (cetirizine hydrochloride) and Florinef (fludrocortisone acetate). Common drug interactions include fibromyalgia among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Zyrtec and Florinef. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,619 Zyrtec users. Check the latest studies of Zyrtec.

What is Florinef?

Florinef has active ingredients of fludrocortisone acetate. It is often used in addison's disease. eHealthMe is studying from 3,834 Florinef users. Check the latest studies of Florinef.

On Jul, 13, 2026

88 people who take Zyrtec and Florinef together, and have interactions are studied.

What are the common drug interactions of Zyrtec and Florinef, by gender? *:

female:

Fibromyalgia (a long-term condition which causes pain all over the body)
Hepatic enzyme increased
Hypercoagulation (increased tendency for clotting of the blood)
Hypoaesthesia (reduced sense of touch or sensation)
Infection
Joint swelling
Loss of consciousness
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Miliaria (a skin disease marked by small and itchy rashes)
Neuralgia (pain in one or more nerves)

male:

Fall
Dehydration (dryness resulting from the removal of water)
Renal failure (kidney dysfunction)
Retinal haemorrhage (bleeding from retina)
Therapeutic response decreased (less preventive response)
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Abdominal pain
Actinic keratosis (skin disease due to sun exposure)
Acute sinusitis
Anxiety

What are the common drug interactions of Zyrtec and Florinef, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Device related infection
Hypertensive emergency

10-19:

Hypertension (high blood pressure)
Headache (pain in head)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Rhinorrhoea (watery mucus discharge from the nose)
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Renal neoplasm (kidney tumour)
Nystagmus (a condition of involuntary eye movement)
Pain
Renal mass (mass in kidney)
Abdominal discomfort

20-29:

Suicidal ideation
Asthma
Anxiety
Insomnia (sleeplessness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hypercoagulation (increased tendency for clotting of the blood)
Nausea (feeling of having an urge to vomit)
Neuralgia (pain in one or more nerves)
Pain in extremity

30-39:

Confusional state
Diarrhoea
Dyskinesia (abnormality or impairment of voluntary movement)
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Miliaria (a skin disease marked by small and itchy rashes)
Pallor
Peripheral coldness
Rash

40-49:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Femoral artery occlusion (obstruction in artery of femur)
Gangrene (body tissue dies)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Impaired healing
Infection
Lividity (a tissue condition of being red or blue because of venous congestion, as in a contusion)
Osteomyelitis (infection of bone)
Skin ulcer
Small intestinal obstruction (blockage in small intestine)

50-59:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematocrit decreased
Haemoglobin decreased
Haemorrhage (bleeding)
Hyperglycaemia (high blood sugar)
Hyperkalaemia (damage to or disease of the kidney)
Hypersensitivity
Hypertension (high blood pressure)
Hypoaldosteronism (decreased levels of the hormone aldosterone)

60+:

Arthropathy
Dry skin
Oedema (fluid collection in tissue)
Pain
Pruritus generalised (generalized itching)
Rash papular (redness with papule)
Scar
Skin discolouration (change of skin colour)
Skin induration (an abnormally hard spot or area on the skin)
Skin tightness

What are the existing conditions these people have? *

Pain: 15 people, 17.05%
Hypersensitivity: 12 people, 13.64%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 12.50%
Depression: 9 people, 10.23%
Asthma: 8 people, 9.09%
Diabetes: 8 people, 9.09%
Stress And Anxiety: 7 people, 7.95%
Nausea (feeling of having an urge to vomit): 7 people, 7.95%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 6.82%
Acne (skin problems that cause pimples): 6 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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