Differin and Vitamin b12 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Differin (adapalene) and Vitamin b12 (cobalamin). Common drug interactions include aortic thrombosis among females.

The phase IV clinical study analyzes what interactions people have when they take Differin and Vitamin b12. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,740 Differin users. Check the latest studies of Differin.

What is Vitamin b12?

Vitamin b12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 121,681 Vitamin b12 users. Check the latest studies of Vitamin b12.

On Jul, 23, 2026

11 people who take Differin and Vitamin b12 together, and have interactions are studied.

Differin and Vitamin b12 drug interactions.

What are the common drug interactions of Differin and Vitamin B12, by gender? *:

female:

Aortic thrombosis (formation of a blood clot inside aorta)
Blepharospasm (any abnormal contraction or twitch of the eyelid)
Hypertension (high blood pressure)
Nasopharyngitis (inflammation of the nasopharynx)
Pain
Anxiety
Aphonia (inability to produce voice)
Asthenia (weakness)
Blood urea increased
Burning sensation

male:

n/a

What are the common drug interactions of Differin and Vitamin B12, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Nasopharyngitis (inflammation of the nasopharynx)

20-29:

n/a

30-39:

Aortic thrombosis (formation of a blood clot inside aorta)
Aphonia (inability to produce voice)
Blepharospasm (any abnormal contraction or twitch of the eyelid)
Cardiac disorder
Dysphonia (speech disorder attributable to a disorder of phonation)
Fibromyalgia (a long-term condition which causes pain all over the body)
Nasopharyngitis (inflammation of the nasopharynx)
Night sweats (sweating in night)
Scar
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

40-49:

n/a

50-59:

Asthenia (weakness)
Burning sensation
Insomnia (sleeplessness)
Muscle spasms (muscle contraction)
Myalgia (muscle pain)
Oral candidiasis (fungal infection of mouth)
Oral pain
Pain in extremity
Rash
Skin disorder (skin disease)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 63.64%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 54.55%
Insomnia (sleeplessness): 3 people, 27.27%
Hypersensitivity: 1 person, 9.09%
Bladder Disorder: 1 person, 9.09%
Depression: 1 person, 9.09%
Drowsiness: 1 person, 9.09%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 9.09%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 9.09%
Stress And Anxiety: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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