Diflucan and Buscopan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diflucan (fluconazole) and Buscopan (hyoscine butylbromide). Common drug interactions include oral soft tissue disorder among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Diflucan and Buscopan. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Diflucan?

Diflucan has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 28,471 Diflucan users. Check the latest studies of Diflucan.

What is Buscopan?

Buscopan has active ingredients of hyoscine butylbromide. eHealthMe is studying from 4,828 Buscopan users. Check the latest studies of Buscopan.

On Jul, 13, 2026

29 people who take Diflucan and Buscopan together, and have interactions are studied.

Diflucan and Buscopan drug interactions.

What are the common drug interactions of Diflucan and Buscopan, by gender? *:

female:

Oral soft tissue disorder (oral soft tissue disease)
Pain
Platelet count increased
Pneumonia
Proctalgia (pain in the rectum)
Pyrexia (fever)
Rash erythematous (redness of the skin)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Renal failure acute (rapid kidney dysfunction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Venoocclusive liver disease (small veins in the liver are obstructed)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Arthralgia (joint pain)
Chronic lymphocytic leukaemia transformation (white blood cell cancer changes in fast growing cancer in lymph node)
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Diflucan and Buscopan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Haemorrhage intracranial (bleeding within the skull)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

20-29:

Hepatic failure (liver failure)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Oedema (fluid collection in tissue)
Platelet count decreased
Renal impairment (severely reduced kidney function)
Septic shock (shock due to blood infection)
Skin striae (irregular areas of skin that look like bands, stripes, or lines)

30-39:

Death

40-49:

Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Acute circulatory failure (shock)
Fungal infection
Mucosal erosion (peeling off of mucous membrane)
Pruritus (severe itching of the skin)
Cardiac failure
Diarrhoea

50-59:

Constipation
Ileus (a painful obstruction of the ileum or other part of the intestine)
Venoocclusive liver disease (small veins in the liver are obstructed)
Abscess (pus)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gingivitis (inflammation of gums)
Lower respiratory tract infection
Oral herpes (viral infection of mouth)
Tooth abscess (pus formation in tooth)
Upper respiratory tract infection

60+:

Blood cholesterol increased
Fall
Abdominal pain
Abdominal pain upper
Chronic lymphocytic leukaemia transformation (white blood cell cancer changes in fast growing cancer in lymph node)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug level decreased
Faeces pale
Febrile neutropenia (fever with reduced white blood cells)
Gamma-glutamyltransferase increased

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.90%
Pain: 2 people, 6.90%
Oedema (fluid collection in tissue): 2 people, 6.90%
Nausea (feeling of having an urge to vomit): 2 people, 6.90%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 2 people, 6.90%
Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 2 people, 6.90%
Lung Infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung): 2 people, 6.90%
Infection: 2 people, 6.90%
Fever: 2 people, 6.90%
Acute Lymphocytic Leukaemia Recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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