Diflucan and Tyvaso drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diflucan (fluconazole) and Tyvaso (treprostinil sodium). Common drug interactions include nasal congestion among females and angina pectoris among males.

The phase IV clinical study analyzes what interactions people have when they take Diflucan and Tyvaso. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Diflucan?

Diflucan has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 28,471 Diflucan users. Check the latest studies of Diflucan.

What is Tyvaso?

Tyvaso has active ingredients of treprostinil sodium. eHealthMe is studying from 37,941 Tyvaso users. Check the latest studies of Tyvaso.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

19 people who take Diflucan and Tyvaso together, and have interactions are studied.

What are the common drug interactions of Diflucan and Tyvaso, by gender? *:

female:

Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Fungal infection
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Oral candidiasis (fungal infection of mouth)
Abscess (pus)
Blood pressure increased
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Drug hypersensitivity
Eye pain

male:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Ascites (accumulation of fluid in the abdominal cavity)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chronic hepatic failure (long lasting liver failure)
Decreased appetite
Diarrhoea
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Oral candidiasis (fungal infection of mouth)
Weight decreased

What are the common drug interactions of Diflucan and Tyvaso, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dyspnoea (difficult or laboured respiration)
Febrile neutropenia (fever with reduced white blood cells)
Headache (pain in head)
Lymphoma (cancer that begins in immune system cells)

50-59:

Abdominal pain upper
Cardiac failure
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Fluid retention (an abnormal accumulation of fluid in the blood)
Oedema peripheral (superficial swelling)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Weight increased
Chronic hepatic failure (long lasting liver failure)
Abscess (pus)

60+:

Diarrhoea
Malaise (a feeling of general discomfort or uneasiness)
Back injury
Back pain
Burning sensation
Cardiomegaly (increased size of heart than normal)
Catheter site discharge
Contusion (a type of hematoma of tissue in which capillaries)
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 15 people, 78.95%
Oral Candidiasis (fungal infection of mouth): 9 people, 47.37%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 6 people, 31.58%
Pharyngitis Streptococcal (inflammation of the pharynx caused by infection from. streptococcus): 5 people, 26.32%
Multiple Allergies (allergy to multiple agents): 5 people, 26.32%
Infection: 5 people, 26.32%
Fungal Infection: 2 people, 10.53%
Sinus Disorder (disease of sinus): 1 person, 5.26%
Gastritis (inflammation of stomach): 1 person, 5.26%
Cardiac Failure: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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