Digoxin and Bromhexine hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Digoxin (digoxin) and Bromhexine hydrochloride (bromhexine hydrochloride). Common drug interactions include alanine aminotransferase increased among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Digoxin and Bromhexine hydrochloride. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Digoxin?

Digoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 93,740 Digoxin users. Check the latest studies of Digoxin.

What is Bromhexine hydrochloride?

Bromhexine hydrochloride has active ingredients of bromhexine hydrochloride. It is often used in cough. eHealthMe is studying from 935 Bromhexine hydrochloride users. Check the latest studies of Bromhexine hydrochloride.



On Jul, 12, 2026

13 people who take Digoxin and Bromhexine hydrochloride together, and have interactions are studied.

Digoxin and Bromhexine hydrochloride drug interactions.

What are the common drug interactions of Digoxin and Bromhexine Hydrochloride, by gender? *:

female:

  1. Alanine aminotransferase increased
  2. Anxiety
  3. Aspartate aminotransferase increased
  4. Asthenia (weakness)
  5. Cardiac failure
  6. Chest discomfort
  7. Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
  8. Device related infection
  9. Erythema (redness of the skin)
  10. Escherichia urinary tract infection (urinary tract infection by escherichia coli)

male:

  1. Renal failure (kidney dysfunction)
  2. Hypotension (abnormally low blood pressure)
  3. Gastroenteritis (inflammation of stomach and intestine)
  4. Headache (pain in head)
  5. Parotitis (inflammation of a parotid gland)
  6. Pneumonia
  7. Upper respiratory tract inflammation
  8. Abdominal pain
  9. Acute circulatory failure (shock)
  10. Alanine aminotransferase increased

What are the common drug interactions of Digoxin and Bromhexine Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Renal failure (kidney dysfunction)
  2. Blood creatinine increased
  3. Blood pressure decreased
  4. Brain natriuretic peptide increased
  5. Cardiac failure
  6. Diarrhoea
  7. Gastroenteritis (inflammation of stomach and intestine)
  8. Headache (pain in head)
  9. Hypotension (abnormally low blood pressure)
  10. Parotitis (inflammation of a parotid gland)

30-39:

  1. Alanine aminotransferase increased
  2. Aspartate aminotransferase increased
  3. Device related infection
  4. Gamma-glutamyltransferase increased
  5. Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
  6. Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)
  7. Right ventricular failure (right half of the heart fails to work)
  8. Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot)

40-49:

n/a

50-59:

  1. Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
  2. Anxiety
  3. Asthenia (weakness)
  4. Cardiac failure
  5. Chest discomfort
  6. Escherichia urinary tract infection (urinary tract infection by escherichia coli)
  7. Hypoglycaemia (deficiency of glucose in the bloodstream)
  8. Myalgia (muscle pain)
  9. Overdose
  10. Restlessness (not able to rest)

60+:

  1. Torsade de pointes (a abnormal heart rate with abnormal beating pattern)
  2. Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
  3. Blood pressure decreased
  4. Brain hypoxia (reduced supply of oxygen to the brain)
  5. Cholecystitis acute (rapid infection of gallbladder)
  6. Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
  7. Delayed recovery from anaesthesia
  8. Depressed level of consciousness
  9. Dyspnoea (difficult or laboured respiration)
  10. Encephalopathy (functioning of the brain is affected by some agent or condition)

What are the existing conditions these people have? *

  1. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 23.08%
  2. Arrhythmias (irregular heartbeat): 2 people, 15.38%
  3. Right Ventricular Failure (right half of the heart fails to work): 2 people, 15.38%
  4. Cardiac Failure: 2 people, 15.38%
  5. Type 2 Diabetes: 1 person, 7.69%
  6. Hypercalcaemia (elevated calcium (ca+) level in the blood): 1 person, 7.69%
  7. Cardiac Disorder: 1 person, 7.69%
  8. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 7.69%
  9. Constipation: 1 person, 7.69%
  10. Dry Eyes (lack of adequate tears): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Digoxin and Bromhexine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Digoxin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Bromhexine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Digoxin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Bromhexine hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on digoxin and bromhexine hydrochloride (the active ingredients of Digoxin and Bromhexine hydrochloride, respectively), and Digoxin and Bromhexine hydrochloride (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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