Digoxin and Buprenorphine hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Digoxin (digoxin) and Buprenorphine hydrochloride (buprenorphine hydrochloride). Common drug interactions include coronary artery disease among females and cardiomyopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Digoxin and Buprenorphine hydrochloride. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Digoxin?

Digoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 93,740 Digoxin users. Check the latest studies of Digoxin.

What is Buprenorphine hydrochloride?

Buprenorphine hydrochloride has active ingredients of buprenorphine hydrochloride. It is often used in pain. eHealthMe is studying from 4,438 Buprenorphine hydrochloride users. Check the latest studies of Buprenorphine hydrochloride.

On Aug, 09, 2026

11 people who take Digoxin and Buprenorphine hydrochloride together, and have interactions are studied.

Digoxin and Buprenorphine hydrochloride drug interactions.

What are the common drug interactions of Digoxin and Buprenorphine Hydrochloride, by gender? *:

female:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Haematuria present (presence of blood in urine due to trauma)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Mitral valve incompetence (inefficient heart valve)
Pulmonary oedema (fluid accumulation in the lungs)
Ventricular hypertrophy (enlargement of ventricles (lower chambers) in the heart)
Cardiac disorder
Echocardiogram abnormal
Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat)

male:

Cardiomyopathy (weakening of the heart muscle)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Diarrhoea
Hyperuricaemia (level of uric acid in the blood that is abnormally high)
Hypoaesthesia (reduced sense of touch or sensation)
Hypokalaemia (low potassium)
Pericardial effusion (fluid around the heart)
Pneumonia
Post procedural complication
Pyrexia (fever)

What are the common drug interactions of Digoxin and Buprenorphine Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arrhythmia (irregular heartbeat)
Blood potassium abnormal
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
Budd chiari syndrome (problem that results from blood clotting in the veins flowing out of the liver (hepatic veins))
Cardiac failure
Cardiac tamponade (fluid accumulates in heart covering)
Diarrhoea
Hyperuricaemia (level of uric acid in the blood that is abnormally high)
Hypoaesthesia (reduced sense of touch or sensation)
Hypokalaemia (low potassium)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Cardiomyopathy (weakening of the heart muscle)

60+:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Haematuria present (presence of blood in urine due to trauma)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Mitral valve incompetence (inefficient heart valve)
Pulmonary oedema (fluid accumulation in the lungs)
Ventricular hypertrophy (enlargement of ventricles (lower chambers) in the heart)
Cardiac disorder
Echocardiogram abnormal
Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat)

What are the existing conditions these people have? *

Sedation: 4 people, 36.36%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 27.27%
Urination - Excessive Volume: 2 people, 18.18%
High Blood Pressure: 2 people, 18.18%
Bleeding Disorders: 2 people, 18.18%
Blood Calcium Decreased: 2 people, 18.18%
Blood Glucose Increased: 2 people, 18.18%
Blood Potassium Decreased: 2 people, 18.18%
Cardiac Failure: 2 people, 18.18%
Constipation: 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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