Dilantin and Cipro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dilantin (phenytoin sodium) and Cipro (ciprofloxacin hydrochloride). Common drug interactions include blood pressure increased among females and blood creatinine increased among males.

The phase IV clinical study analyzes what interactions people have when they take Dilantin and Cipro. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,858 Dilantin users. Check the latest studies of Dilantin.

What is Cipro?

Cipro has active ingredients of ciprofloxacin hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 35,126 Cipro users. Check the latest studies of Cipro.

On Aug, 06, 2026

90 people who take Dilantin and Cipro together, and have interactions are studied.

What are the common drug interactions of Dilantin and Cipro, by gender? *:

female:

Blood pressure increased
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Blood triglycerides increased
Burning sensation
Loss of consciousness
Abdominal pain
Pain
Cough
Fall
Hypoaesthesia (reduced sense of touch or sensation)

male:

Blood creatinine increased
Cardiac failure congestive
Eye rolling
Haematuria present (presence of blood in urine due to trauma)
Injury
Lethargy (tiredness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Neoplasm malignant (cancer tumour)
Pain
Prostatitis (inflammation of the prostate gland)

What are the common drug interactions of Dilantin and Cipro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal distension
Abdominal pain
Anaemia (lack of blood)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Blood pressure increased
Blood triglycerides increased
Burning sensation
Carbuncle (a carbuncle is an abscess larger than a boil)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

30-39:

Fatigue (feeling of tiredness)
Nail discolouration (change in nail colour)

40-49:

Abdominal pain
Faecal incontinence (a lack of control over passing stool)
Flatulence (flatus expelled through the anus)
Somnolence (a state of near-sleep, a strong desire for sleep)
Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Dry mouth
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hypoaesthesia (reduced sense of touch or sensation)

50-59:

Oedema peripheral (superficial swelling)
Osteoporosis (bones weak and more likely to break)
Pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug ineffective
Intervertebral disc degeneration (spinal disc degeneration)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Abdominal pain
Acute sinusitis
Alopecia (absence of hair from areas of the body)

60+:

Cough
Blood creatinine increased
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Dizziness
Dry eye (lack of adequate tears)
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Injury
Lung neoplasm (tumour of lung)
Rales (an abnormal respiratory sound characterized by fine crackles)

What are the existing conditions these people have? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 11 people, 12.22%
Infection: 6 people, 6.67%
High Blood Pressure: 6 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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