Dilantin and Isoniazid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dilantin (phenytoin sodium) and Isoniazid (isoniazid). Common drug interactions include stevens-johnson syndrome among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Dilantin and Isoniazid. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,858 Dilantin users. Check the latest studies of Dilantin.

What is Isoniazid?

Isoniazid has active ingredients of isoniazid. It is often used in tuberculosis. eHealthMe is studying from 20,174 Isoniazid users. Check the latest studies of Isoniazid.

On Aug, 03, 2026

20 people who take Dilantin and Isoniazid together, and have interactions are studied.

Dilantin and Isoniazid drug interactions.

What are the common drug interactions of Dilantin and Isoniazid, by gender? *:

female:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Aplasia pure red cell (type of anaemia affecting the precursors to red blood cells but not to white blood cells)
Meningioma (a diverse set of tumours arising from the meninges)
Staphylococcal bacteraemia (a bacterial infection of blood)
Anti-erythropoietin antibody positive
Confusional state
Therapeutic response decreased (less preventive response)
Anaemia (lack of blood)
Ankle fracture
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

male:

Cardiac failure congestive
Coma (state of unconsciousness lasting more than six hours)
Nystagmus (a condition of involuntary eye movement)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Rash erythematous (redness of the skin)
Rash vesicular (rash with a small bubble)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Drug ineffective

What are the common drug interactions of Dilantin and Isoniazid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

10-19:

n/a

20-29:

Ankle fracture
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Emotional disorder
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Oedema (fluid collection in tissue)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Sinus arrhythmia (a naturally occurring variation in heart rate that occurs during a breathing cycle)
Skin infection
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

30-39:

Abortion spontaneous (naturally occurring miscarriage)

40-49:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)

50-59:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Drug ineffective

60+:

Nystagmus (a condition of involuntary eye movement)
Cardiac failure congestive
Rash vesicular (rash with a small bubble)
Coma (state of unconsciousness lasting more than six hours)
Confusion
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Drug toxicity
Fall
Hyperkalaemia (damage to or disease of the kidney)
Lactic acidosis (low ph in body tissues)

What are the existing conditions these people have? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 25.00%
Chronic Renal Failure (kidney failure): 4 people, 20.00%
Latent Tuberculosis (hidden tuberculosis): 2 people, 10.00%
Stress And Anxiety: 1 person, 5.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.00%
Nuclear Magnetic Resonance Imaging Brain: 1 person, 5.00%
Irritable Bowel Syndrome: 1 person, 5.00%
Hypersensitivity: 1 person, 5.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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