Dilantin and Onfi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dilantin (phenytoin sodium) and Onfi (clobazam). Common drug interactions include visual impairment among females and convulsion among males.

The phase IV clinical study analyzes what interactions people have when they take Dilantin and Onfi. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,858 Dilantin users. Check the latest studies of Dilantin.

What is Onfi?

Onfi has active ingredients of clobazam. It is often used in epilepsy. eHealthMe is studying from 7,809 Onfi users. Check the latest studies of Onfi.

On Jul, 12, 2026

77 people who take Dilantin and Onfi together, and have interactions are studied.

What are the common drug interactions of Dilantin and Onfi, by gender? *:

female:

Visual impairment
Vomiting
Aggression
Confusional state
Abnormal dreams
Alopecia (absence of hair from areas of the body)
Anger
Arthralgia (joint pain)
Blood cholesterol increased
Clavicle fracture

male:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fall
Somnolence (a state of near-sleep, a strong desire for sleep)
Drug withdrawal convulsions
Migraine (headache)
Fatigue (feeling of tiredness)
Memory impairment
Abasia (inability to walk)
Asthenia (weakness)
Cough

What are the common drug interactions of Dilantin and Onfi, by age (0-1 to 60+)? *:

0-1:

Death
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Pyrexia (fever)
Vomiting

2-9:

Diarrhoea
Body temperature decreased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Urinary tract infection
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Body temperature increased
Constipation
Drooling (drop saliva uncontrollably from the mouth)
Inappropriate affect
Lacrimation increased

10-19:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Neoplasm (tumour)
Personality change
Renal disorder (kidney disease)
Seizure cluster (small group of seizure)
Somnolence (a state of near-sleep, a strong desire for sleep)
Stomatitis (inflammation of mucous membrane of mouth)
Vitamin d decreased
Weight increased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

20-29:

Fall
Abnormal behaviour
Anticonvulsant drug level decreased
Clavicle fracture
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Depression
Drop attacks (sudden spontaneous falls while standing or walking)
Muscle twitching
Pneumonia
Renal failure (kidney dysfunction)

30-39:

Anxiety
Cold-stimulus headache (headache by cold exposure)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Road traffic accident
Muscle spasms (muscle contraction)

40-49:

Fall
Cerebellar ataxia (loss of coordination)
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dysarthria (speech disorder)
Pain
Migraine (headache)
Memory impairment
Abasia (inability to walk)

50-59:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Pneumonia
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Glioblastoma multiforme (most common and deadliest of malignant primary brain tumours in adults)

60+:

Circulatory collapse
Abnormal dreams
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Labyrinthitis (inflammation of the labyrinth or inner ear)
Nausea (feeling of having an urge to vomit)
Pneumonia
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Pruritus (severe itching of the skin)
Sedation

What are the existing conditions these people have? *

Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 15 people, 19.48%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 7 people, 9.09%
Complex Partial Seizures (epileptic seizure): 7 people, 9.09%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 6.49%
Infantile Spasms: 5 people, 6.49%

* Approximation only. Some reports may have incomplete information.

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