Kayexalate and Multihance drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Kayexalate (sodium polystyrene sulfonate) and Multihance (gadobenate dimeglumine). Common drug interactions include anhedonia among females and nephrogenic systemic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Kayexalate and Multihance. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Kayexalate?

Kayexalate has active ingredients of sodium polystyrene sulfonate. eHealthMe is studying from 5,004 Kayexalate users. Check the latest studies of Kayexalate.

What is Multihance?

Multihance has active ingredients of gadobenate dimeglumine. eHealthMe is studying from 5,786 Multihance users. Check the latest studies of Multihance.

On Jul, 12, 2026

19 people who take Kayexalate and Multihance together, and have interactions are studied.

Kayexalate and Multihance drug interactions.

What are the common drug interactions of Kayexalate and Multihance, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Asthenia (weakness)
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Mobility decreased (ability to move is reduced)
Muscle tightness
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

male:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Rash
Skin induration (an abnormally hard spot or area on the skin)
Joint contracture (a permanent shortening of a muscle or joint)
Skin discolouration (change of skin colour)
Erythema (redness of the skin)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Skin fibrosis (fibrous tissue formation on skin)
Hypoaesthesia (reduced sense of touch or sensation)

What are the common drug interactions of Kayexalate and Multihance, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Joint stiffness
Mobility decreased (ability to move is reduced)
Muscle tightness
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Pruritus generalised (generalized itching)
Rash erythematous (redness of the skin)
Scar
Skin discolouration (change of skin colour)

30-39:

n/a

40-49:

Joint contracture (a permanent shortening of a muscle or joint)
Joint range of motion decreased (disease of joint movement)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Skin hypertrophy (skin cells enlarges)
Skin induration (an abnormally hard spot or area on the skin)
Pain of skin
Skin atrophy (wasting of skin)
Skin fibrosis (fibrous tissue formation on skin)
Skin hyperpigmentation (disorders affect the colour of your skin)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Dry skin
Emotional distress
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Injury
Joint stiffness
Mobility decreased (ability to move is reduced)

60+:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Pruritus (severe itching of the skin)
Skin discolouration (change of skin colour)
Depression
Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers)
Erythema (redness of the skin)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Ischaemic ulcer (arterial ulcer)
Joint contracture (a permanent shortening of a muscle or joint)

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 8 people, 42.11%
Rash Pruritic (redness with itching): 3 people, 15.79%
Anaemia (lack of blood): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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