Dilantin and Relpax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dilantin (phenytoin sodium) and Relpax (eletriptan hydrobromide). Common drug interactions include intervertebral disc protrusion among females and blood iron decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Dilantin and Relpax. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,858 Dilantin users. Check the latest studies of Dilantin.

What is Relpax?

Relpax has active ingredients of eletriptan hydrobromide. It is often used in migraine. eHealthMe is studying from 9,259 Relpax users. Check the latest studies of Relpax.



On Jul, 26, 2026

12 people who take Dilantin and Relpax together, and have interactions are studied.

Dilantin and Relpax drug interactions.

What are the common drug interactions of Dilantin and Relpax, by gender? *:

female:

  1. Intervertebral disc protrusion (spinal disc protrusion)
  2. Low density lipoprotein increased (cholesterol increased in blood)
  3. Pneumonia
  4. Drug abuser
  5. Drug ineffective
  6. Hypoaesthesia (reduced sense of touch or sensation)
  7. Overdose
  8. Photosensitivity reaction
  9. Rib fracture
  10. Abdominal pain

male:

  1. Blood iron decreased
  2. Memory impairment

What are the common drug interactions of Dilantin and Relpax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Appendicitis (inflammation of the appendix)
  2. Cholecystitis chronic (long lasting infection of gallbladder)
  3. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  4. Gallbladder disorder
  5. Pain

30-39:

  1. Injection site urticaria (rash of round, red welts on the skin at injection site)

40-49:

n/a

50-59:

  1. Blood iron decreased
  2. Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
  3. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  4. Blood triglycerides increased
  5. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  6. Gallbladder operation
  7. High density lipoprotein decreased
  8. Hypotension (abnormally low blood pressure)
  9. Injury
  10. Intervertebral disc protrusion (spinal disc protrusion)

60+:

  1. Drug ineffective
  2. Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
  3. Low density lipoprotein increased (cholesterol increased in blood)
  4. Pneumonia
  5. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  6. Blood triglycerides increased
  7. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  8. Gallbladder operation
  9. High density lipoprotein decreased
  10. Hypotension (abnormally low blood pressure)

What are the existing conditions these people have? *

  1. Headache (pain in head): 3 people, 25.00%
  2. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 25.00%
  3. Temporomandibular Joint Syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress): 2 people, 16.67%
  4. Erection Problems: 2 people, 16.67%
  5. Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 16.67%
  6. Stress And Anxiety: 1 person, 8.33%
  7. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 8.33%
  8. Premenstrual Syndrome: 1 person, 8.33%
  9. Nerve Block (the interruption of signals travelling along a nerve): 1 person, 8.33%
  10. Muscle Tightness: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Dilantin and Relpax:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Dilantin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Relpax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Dilantin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Relpax and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on phenytoin sodium and eletriptan hydrobromide (the active ingredients of Dilantin and Relpax, respectively), and Dilantin and Relpax (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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