Dilantin and Soliris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dilantin (phenytoin sodium) and Soliris (eculizumab). Common drug interactions include upper respiratory tract infection among females and haemoglobin decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Dilantin and Soliris. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,858 Dilantin users. Check the latest studies of Dilantin.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

On Aug, 05, 2026

18 people who take Dilantin and Soliris together, and have interactions are studied.

What are the common drug interactions of Dilantin and Soliris, by gender? *:

female:

Upper respiratory tract infection
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Anxiety
Arteriovenous fistula site infection
Oedema (fluid collection in tissue)
Somnolence (a state of near-sleep, a strong desire for sleep)

male:

Haemoglobin decreased
Drug ineffective
Burning sensation
Chills (felling of cold)
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fall
Memory impairment
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Neutropenia (an abnormally low number of neutrophils)

What are the common drug interactions of Dilantin and Soliris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chills (felling of cold)
Neutropenia (an abnormally low number of neutrophils)

30-39:

Drug ineffective
Haemoglobin decreased
Infection
Influenza
Platelet count decreased
Sinusitis (inflammation of sinus)

40-49:

Anxiety
Arteriovenous fistula site infection
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Oedema (fluid collection in tissue)
Somnolence (a state of near-sleep, a strong desire for sleep)

50-59:

n/a

60+:

Anaemia (lack of blood)
Upper respiratory tract infection
Memory impairment
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Pain in extremity
Pneumonia
Ventricular extrasystoles (premature cardiac contraction)
Visual field defect
Weight decreased
Blood lactate dehydrogenase increased

What are the existing conditions these people have? *

Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 13 people, 72.22%
Pain: 4 people, 22.22%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 4 people, 22.22%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 16.67%
Constipation: 2 people, 11.11%
Nausea (feeling of having an urge to vomit): 2 people, 11.11%
Headache (pain in head): 2 people, 11.11%
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium): 1 person, 5.56%
Diabetes: 1 person, 5.56%
Fever: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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