Dilaudid and Eplerenone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dilaudid (hydromorphone hydrochloride) and Eplerenone (eplerenone). Common drug interactions include progressive multifocal leukoencephalopathy among females and progressive multifocal leukoencephalopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Dilaudid and Eplerenone. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Dilaudid?

Dilaudid has active ingredients of hydromorphone hydrochloride. It is often used in pain. eHealthMe is studying from 96,466 Dilaudid users. Check the latest studies of Dilaudid.

What is Eplerenone?

Eplerenone has active ingredients of eplerenone. It is often used in high blood pressure. eHealthMe is studying from 9,979 Eplerenone users. Check the latest studies of Eplerenone.

On Jul, 07, 2026

16 people who take Dilaudid and Eplerenone together, and have interactions are studied.

Dilaudid and Eplerenone drug interactions.

What are the common drug interactions of Dilaudid and Eplerenone, by gender? *:

female:

Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Hallucination (an experience involving the perception of something not present)
Bladder disorder
Cardiac failure
Dyspepsia (indigestion)
Loss of consciousness
Renal failure (kidney dysfunction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Seizure like phenomena (a variety of medical conditions may produce sudden episodes which have some similarities to epileptic seizures)
Syncope (loss of consciousness with an inability to maintain postural tone)

male:

Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Blood culture positive
Blood glucose increased
Confusional state
Death
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Headache (pain in head)
Hypophagia (reduced food intake)

What are the common drug interactions of Dilaudid and Eplerenone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Blood glucose increased
Death

30-39:

n/a

40-49:

Bladder disorder
Cardiac failure
Dyspepsia (indigestion)
Loss of consciousness
Renal failure (kidney dysfunction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Seizure like phenomena (a variety of medical conditions may produce sudden episodes which have some similarities to epileptic seizures)
Syncope (loss of consciousness with an inability to maintain postural tone)

50-59:

Atelectasis (partial or complete collapse of the lung)
Blood culture positive
Confusional state
Hallucination, auditory (perceiving sounds without auditory stimulus)
Headache (pain in head)
Hypophagia (reduced food intake)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Photophobia (extreme sensitivity to light)
Pneumonia
Speech disorder

60+:

Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Renal impairment (severely reduced kidney function)
Anxiety
Chronic kidney disease
Depression
Emotional distress
Hallucination (an experience involving the perception of something not present)
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Tremor (trembling or shaking movements in one or more parts of your body): 10 people, 62.50%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 62.50%
Laryngospasm (an uncontrolled/involuntary muscular contraction of larynx): 10 people, 62.50%
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough): 10 people, 62.50%
Vitamin B12 Deficiency: 1 person, 6.25%
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 1 person, 6.25%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 6.25%
Pain In Extremity: 1 person, 6.25%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 6.25%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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