Dilaudid and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dilaudid (hydromorphone hydrochloride) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include night sweats among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Dilaudid and Excedrin. It is created by eHealthMe based on reports of 100 people who take the same drugs from the FDA, and is updated regularly.

What is Dilaudid?

Dilaudid has active ingredients of hydromorphone hydrochloride. It is often used in pain. eHealthMe is studying from 96,466 Dilaudid users. Check the latest studies of Dilaudid.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

100 people who take Dilaudid and Excedrin together, and have interactions are studied.

Dilaudid and Excedrin drug interactions.

What are the common drug interactions of Dilaudid and Excedrin, by gender? *:

female:

Night sweats (sweating in night)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood calcium increased
Bone pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chronic kidney disease
Drug dependence
Eye disorder
Gastric disorder (disease of stomach)
Herpes simplex (herpes simplex is a common viral infection)

male:

Back pain
Blood pressure fluctuation
Vomiting
Chronic kidney disease
Colitis (inflammation of colon)
Fatigue (feeling of tiredness)
Feeling hot
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Leukopenia (less number of white blood cells in blood)
Lymphocytosis (an increase in the number or proportion of lymphocytes in the blood)

What are the common drug interactions of Dilaudid and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Intracranial venous sinus thrombosis (presence of thrombosis (a blood clot) in the dural venous sinuses, which drain blood from the brain)

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Device failure
Fall
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Respiratory failure (inadequate gas exchange by the respiratory system)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Blood potassium decreased
Chronic kidney disease
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Drug ineffective

30-39:

Vomiting
Dyspnoea (difficult or laboured respiration)
Pulmonary embolism (blockage of the main artery of the lung)
Back pain
Blood pressure fluctuation
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Dizziness
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)

40-49:

Drug hypersensitivity
Catheter site discharge
Cellulitis (infection under the skin)
Chronic kidney disease
Gastric perforation (hole in stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Impaired gastric emptying
Infection
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pseudomonal sepsis (pseudomonas infections are diseases caused by a bacterium from the genus pseudomonas)

50-59:

Depression
Drug hypersensitivity
Gastric disorder (disease of stomach)
Herpes simplex (herpes simplex is a common viral infection)
Muscle spasms (muscle contraction)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Small intestinal obstruction (blockage in small intestine)
Surgery
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)

60+:

Constipation
Decreased appetite
Chest discomfort
Dysgeusia (disorder of the sense of taste)
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphonia (speech disorder attributable to a disorder of phonation)
Fatigue (feeling of tiredness)
Muscular weakness (muscle weakness)
Ocular discomfort (a generic expression when there is lack of ease in/about the eyes)
Pleural effusion (water on the lungs)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 20 people, 20.00%
Migraine (headache): 17 people, 17.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 16 people, 16.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 12.00%
Nausea (feeling of having an urge to vomit): 10 people, 10.00%
Stress And Anxiety: 9 people, 9.00%
High Blood Pressure: 9 people, 9.00%
Depression: 7 people, 7.00%
Nausea And Vomiting: 6 people, 6.00%
Hereditary Angioedema (recurrent episodes of severe swelling): 6 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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