Dilaudid and Imodium a-d drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dilaudid (hydromorphone hydrochloride) and Imodium a-d (loperamide hydrochloride). Common drug interactions include hypophagia among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Dilaudid and Imodium a-d. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Dilaudid?

Dilaudid has active ingredients of hydromorphone hydrochloride. It is often used in pain. eHealthMe is studying from 96,466 Dilaudid users. Check the latest studies of Dilaudid.

What is Imodium a-d?

Imodium a-d has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 8,944 Imodium a-d users. Check the latest studies of Imodium a-d.



On Jul, 11, 2026

63 people who take Dilaudid and Imodium a-d together, and have interactions are studied.

Dilaudid and Imodium a-d drug interactions.

What are the common drug interactions of Dilaudid and Imodium A-D, by gender? *:

female:

  1. Hypophagia (reduced food intake)
  2. Insomnia (sleeplessness)
  3. Lactose intolerance (inability to digest lactose)
  4. Malaise (a feeling of general discomfort or uneasiness)
  5. Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
  6. Oropharyngeal pain
  7. Pneumonia
  8. Pyrexia (fever)
  9. Reading disorder (problem in areas of the brain that help interpret language)
  10. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

male:

  1. Dyspnoea (difficult or laboured respiration)
  2. Malignant neoplasm progression (cancer tumour came back)
  3. Osteopenia (a condition where bone mineral density is lower than normal)
  4. Osteoporosis (bones weak and more likely to break)
  5. Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  6. White blood cell count decreased
  7. Haematemesis (vomiting of blood)
  8. Abdominal distension
  9. Abdominal pain
  10. Abdominal pain lower

What are the common drug interactions of Dilaudid and Imodium A-D, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Klebsiella test positive
  2. Urinary tract infection

20-29:

  1. Proctalgia (pain in the rectum)

30-39:

n/a

40-49:

  1. Hair colour changes
  2. Alopecia (absence of hair from areas of the body)
  3. Alopecia areata (patchy baldness that typically begins with rapid hair loss)
  4. Alopecia totalis (loss of all head hair)
  5. Drug dependence
  6. Hair disorder
  7. Syncope (loss of consciousness with an inability to maintain postural tone)
  8. White blood cell count decreased

50-59:

  1. Emotional distress
  2. Encephalopathy (functioning of the brain is affected by some agent or condition)
  3. Eructation (release of gas from the digestive tract)
  4. Full blood count decreased
  5. Hilar lymphadenopathy (disease of the lymph nodes due to infection)
  6. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  7. Hypotension (abnormally low blood pressure)
  8. Leukocytosis (increased white blood cells)
  9. Lymphadenopathy mediastinal (an enlargement of the lymph nodes in the part of the chest that separates the lungs)
  10. Malignant neoplasm progression (cancer tumour came back)

60+:

  1. Dyspnoea (difficult or laboured respiration)
  2. Asthenia (weakness)
  3. Concussion (short loss of normal brain function in response to a head injury)
  4. Constipation
  5. Contusion (a type of hematoma of tissue in which capillaries)
  6. Death
  7. Dehydration (dryness resulting from the removal of water)
  8. Faecal incontinence (a lack of control over passing stool)
  9. Feeling cold
  10. Feeling hot

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 21 people, 33.33%
  2. Nausea (feeling of having an urge to vomit): 11 people, 17.46%
  3. Depression: 8 people, 12.70%
  4. Stress And Anxiety: 7 people, 11.11%
  5. Nausea And Vomiting: 5 people, 7.94%
  6. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 6.35%

* Approximation only. Some reports may have incomplete information.

Do you take Dilaudid and Imodium a-d?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Dilaudid and Imodium a-d:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Dilaudid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Imodium a-d:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Dilaudid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Imodium a-d and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on hydromorphone hydrochloride and loperamide hydrochloride (the active ingredients of Dilaudid and Imodium a-d, respectively), and Dilaudid and Imodium a-d (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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