Dilaudid and Xywav drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dilaudid (hydromorphone hydrochloride) and Xywav (calcium oxybate; magnesium oxybate; potassium oxybate; sodium oxybate). Common drug interactions include muscle spasms among females and hospitalisation among males.

The phase IV clinical study analyzes what interactions people have when they take Dilaudid and Xywav. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Dilaudid?

Dilaudid has active ingredients of hydromorphone hydrochloride. It is often used in pain. eHealthMe is studying from 96,466 Dilaudid users. Check the latest studies of Dilaudid.

What is Xywav?

Xywav has active ingredients of calcium oxybate; magnesium oxybate; potassium oxybate; sodium oxybate. eHealthMe is studying from 7,134 Xywav users. Check the latest studies of Xywav.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

29 people who take Dilaudid and Xywav together, and have interactions are studied.

What are the common drug interactions of Dilaudid and Xywav, by gender? *:

female:

Muscle spasms (muscle contraction)
Knee arthroplasty
Nausea (feeling of having an urge to vomit)
Tendon rupture (tear of tendon)
Fall
Head injury
Subdural haematoma (blood collects between the skull and the surface of the brain)
Anxiety
Cellulitis (infection under the skin)
Hospitalisation

male:

Hospitalisation
Migraine (headache)
Tinnitus (a ringing in the ears)
Arrhythmia (irregular heartbeat)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Chest pain
Diabetic nephropathy (diabetic kidney disease)
Drug hypersensitivity
Foot fracture
Hyperkalaemia (damage to or disease of the kidney)

What are the common drug interactions of Dilaudid and Xywav, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hospitalisation
Agitation (state of anxiety or nervous excitement)
Craniocerebral injury (injury to cranium and brain)
Hepatic enzyme increased
Migraine (headache)
Overdose
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Snoring
Suicidal ideation
Suicide attempt

40-49:

Cellulitis (infection under the skin)
Retching (strong involuntary effort to vomit)
Rotator cuff repair
Sleep disorder
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Menopause (end of monthly cycles in women)
Post procedural complication

50-59:

Nausea (feeling of having an urge to vomit)
Anxiety
Breast cancer
Muscle spasms (muscle contraction)
Panic attack
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Chronic kidney disease
Dizziness
Head discomfort
Hyperhidrosis (abnormally increased sweating)

60+:

Knee arthroplasty
Tendon rupture (tear of tendon)
Brain injury
Diplopia (double vision)
Eye infection
Hypotension (abnormally low blood pressure)
Uterine disorder
Accident
Adrenocortical carcinoma (adrenal cortex cancer)
Breakthrough pain

What are the existing conditions these people have? *

Drowsiness: 27 people, 93.10%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 22 people, 75.86%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 19 people, 65.52%
High Blood Pressure: 2 people, 6.90%
Headache (pain in head): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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