Dilaudid and Zemuron drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dilaudid (hydromorphone hydrochloride) and Zemuron (rocuronium bromide). Common drug interactions include enterocutaneous fistula among females and bradycardia among males.

The phase IV clinical study analyzes what interactions people have when they take Dilaudid and Zemuron. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Dilaudid?

Dilaudid has active ingredients of hydromorphone hydrochloride. It is often used in pain. eHealthMe is studying from 96,466 Dilaudid users. Check the latest studies of Dilaudid.

What is Zemuron?

Zemuron has active ingredients of rocuronium bromide. eHealthMe is studying from 873 Zemuron users. Check the latest studies of Zemuron.



On Jul, 16, 2026

63 people who take Dilaudid and Zemuron together, and have interactions are studied.

Dilaudid and Zemuron drug interactions.

What are the common drug interactions of Dilaudid and Zemuron, by gender? *:

female:

  1. Enterocutaneous fistula
  2. Leukocytosis (increased white blood cells)
  3. Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
  4. Small intestinal obstruction (blockage in small intestine)
  5. Apnoea (suspension of external breathing)
  6. Paralysis
  7. Brain hypoxia (reduced supply of oxygen to the brain)
  8. Disseminated intravascular coagulation (systemic activation of blood coagulation)
  9. Pulmonary embolism (blockage of the main artery of the lung)
  10. Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

male:

  1. Bradycardia (abnormally slow heart action)
  2. Blood creatinine increased
  3. Bone marrow failure
  4. Chronic kidney disease
  5. Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
  6. Cytokine storm (over-protective immune response that can actually be fatal)
  7. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  8. Haematuria (presence of blood in urine)
  9. Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
  10. Hypertension (high blood pressure)

What are the common drug interactions of Dilaudid and Zemuron, by age (0-1 to 60+)? *:

0-1:

  1. Capillary leak syndrome (capillary leaks plasma)
  2. Hypotension (abnormally low blood pressure)

2-9:

  1. Hypertension (high blood pressure)
  2. Infection
  3. Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
  4. Diarrhoea
  5. Diarrhoea haemorrhagic (bloody diarrhoea)
  6. Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
  7. Haematoma (collection of blood outside the blood vessels)
  8. Pleural effusion (water on the lungs)
  9. Pyrexia (fever)
  10. Septic shock (shock due to blood infection)

10-19:

  1. Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
  2. Blood creatinine increased
  3. Blood lactic acid increased
  4. Blood urea increased
  5. Bone marrow failure
  6. Bradycardia (abnormally slow heart action)
  7. Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
  8. Cytokine storm (over-protective immune response that can actually be fatal)
  9. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  10. Haematuria (presence of blood in urine)

20-29:

  1. Abdominal pain
  2. Device dislocation
  3. Dyspareunia (painful sexual intercourse)
  4. Infection
  5. Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
  6. Pelvic pain
  7. Uterine perforation (accidental puncture of the uterus)

30-39:

  1. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  2. Atrioventricular block complete (heart block complete)
  3. Blood triglycerides increased
  4. Bradycardia (abnormally slow heart action)
  5. Cardiac arrest
  6. Cardiogenic shock (inadequate circulation of blood)
  7. Electrocardiogram qt prolonged
  8. General physical health deterioration (weak health status)
  9. Hepatic steatosis (fatty liver disease)
  10. Hepatitis (inflammation of the liver)

40-49:

  1. Anxiety
  2. Blood creatinine increased
  3. Bone density decreased
  4. Cellulitis (infection under the skin)
  5. Coma (state of unconsciousness lasting more than six hours)
  6. Dyspnoea (difficult or laboured respiration)
  7. Exposed bone in jaw
  8. Groin abscess (pus in groin)
  9. Haemangioma of skin (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
  10. Hip arthroplasty

50-59:

  1. Cellulitis (infection under the skin)
  2. Gas gangrene (bacterial infection that produces gas within tissues)
  3. Groin abscess (pus in groin)
  4. Groin pain
  5. Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
  6. Scrotal cyst (cyst of scrotum)
  7. Scrotal pain
  8. Scrotal swelling
  9. Testicular pain (pain in testes)
  10. Acute circulatory failure (shock)

60+:

  1. Leukocytosis (increased white blood cells)
  2. Abdominal infection
  3. Post procedural complication
  4. Post procedural haemorrhage (post procedural bleeding)
  5. Psychotic disorder
  6. Respiratory depression (respiration has a rate below 12 breaths)
  7. Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
  8. Drug resistance (reduction in effectiveness of a drug)
  9. Acute hepatic failure
  10. Acute respiratory failure

What are the existing conditions these people have? *

  1. Hypotension (abnormally low blood pressure): 12 people, 19.05%
  2. High Blood Pressure: 11 people, 17.46%
  3. Constipation: 9 people, 14.29%
  4. Nausea (feeling of having an urge to vomit): 9 people, 14.29%
  5. Type 2 Diabetes: 7 people, 11.11%
  6. Depression: 7 people, 11.11%
  7. Stress And Anxiety: 6 people, 9.52%
  8. Anaesthesia: 6 people, 9.52%
  9. Nausea And Vomiting: 5 people, 7.94%
  10. Cardiac Disorder: 5 people, 7.94%

* Approximation only. Some reports may have incomplete information.

Do you take Dilaudid and Zemuron?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Dilaudid and Zemuron:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Dilaudid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zemuron:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Dilaudid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zemuron and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on hydromorphone hydrochloride and rocuronium bromide (the active ingredients of Dilaudid and Zemuron, respectively), and Dilaudid and Zemuron (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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