Diovan and Saphris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diovan (valsartan) and Saphris (asenapine maleate). Common drug interactions include depression among females and attention deficit hyperactivity disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Diovan and Saphris. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Diovan?

Diovan has active ingredients of valsartan. It is often used in high blood pressure. eHealthMe is studying from 83,153 Diovan users. Check the latest studies of Diovan.

What is Saphris?

Saphris has active ingredients of asenapine maleate. It is often used in bipolar i disorder. eHealthMe is studying from 8,688 Saphris users. Check the latest studies of Saphris.

On Jul, 10, 2026

16 people who take Diovan and Saphris together, and have interactions are studied.

What are the common drug interactions of Diovan and Saphris, by gender? *:

female:

Depression
Back disorder
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Intervertebral disc disorder (spinal disc disorder)
Joint swelling
Migraine (headache)
Abdominal pain
Ankle fracture
Arrhythmia (irregular heartbeat)

male:

Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Blood cholesterol increased
Insomnia (sleeplessness)
Nasopharyngitis (inflammation of the nasopharynx)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Sleep disorder
Sleep-related eating disorder (abnormal eating patterns during the night)
Snoring

What are the common drug interactions of Diovan and Saphris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Blood cholesterol increased
Blood creatine phosphokinase increased
Chest pain
Enuresis (repeated inability to control urination)
Haematochezia (passage of stools containing blood)
Hepatic steatosis (fatty liver disease)
Hypersomnia (excessive daytime sleepiness (eds))
Hypotension (abnormally low blood pressure)
Infection

50-59:

Anxiety
Arrhythmia (irregular heartbeat)
Muscle spasms (muscle contraction)
Pain in extremity
Spinal pain (pain in spine)
Arthralgia (joint pain)
Back pain
Blood potassium decreased
Cardiac disorder
Chest pain

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 25.00%
Bipolar Disorder (mood disorder): 4 people, 25.00%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 2 people, 12.50%
Drowsiness: 2 people, 12.50%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 12.50%
Stress And Anxiety: 1 person, 6.25%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 6.25%
Post-Traumatic Stress Disorder: 1 person, 6.25%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 1 person, 6.25%
Hepatitis C: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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