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Mytesi and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mytesi (crofelemer) and Profen (ibuprofen). Common drug interactions include anxiety among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Mytesi and Profen. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Mytesi?

Mytesi has active ingredients of crofelemer. eHealthMe is studying from 201 Mytesi users. Check the latest studies of Mytesi.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

On Jul, 10, 2026

15 people who take Mytesi and Profen together, and have interactions are studied.

Mytesi and Profen drug interactions.

What are the common drug interactions of Mytesi and Profen, by gender? *:

female:

  1. Anxiety
  2. Arthralgia (joint pain)
  3. Depression
  4. Emotional distress
  5. Fracture
  6. Fractured sacrum
  7. Gait disturbance
  8. Hip fracture
  9. Joint dislocation (a joint position is changed from normal position)
  10. Joint injury

male:

  1. Anxiety
  2. Emotional distress
  3. Bedridden
  4. Blood creatinine increased
  5. Femur fracture
  6. Renal tubular necrosis (death of kidney tubules)
  7. Bone density decreased
  8. Osteonecrosis (death of bone)
  9. Renal injury (kidney injury)
  10. Cough

What are the common drug interactions of Mytesi and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Anxiety
  2. Arthralgia (joint pain)
  3. Depression
  4. Emotional distress
  5. Fracture
  6. Fractured sacrum
  7. Gait disturbance
  8. Hip fracture
  9. Joint dislocation (a joint position is changed from normal position)
  10. Joint injury

40-49:

  1. Anxiety
  2. Emotional distress
  3. Hip fracture
  4. Anaemia (lack of blood)
  5. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  6. Ankle fracture
  7. Bedridden
  8. Blood creatinine increased
  9. Chronic kidney disease
  10. Depression

50-59:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Blood creatinine increased
  4. Depression
  5. Diarrhoea
  6. Femur fracture
  7. Foot fracture
  8. Hip fracture
  9. Osteopenia (a condition where bone mineral density is lower than normal)
  10. Renal injury (kidney injury)

60+:

n/a

What are the existing conditions these people have? *

  1. Hiv Infection: 10 people, 66.67%
  2. Diarrhea: 8 people, 53.33%
  3. Stress And Anxiety: 5 people, 33.33%
  4. Depression: 5 people, 33.33%
  5. High Blood Cholesterol: 5 people, 33.33%
  6. High Blood Pressure: 5 people, 33.33%
  7. Hypersensitivity: 5 people, 33.33%
  8. Insomnia (sleeplessness): 5 people, 33.33%
  9. Nausea (feeling of having an urge to vomit): 5 people, 33.33%
  10. Asthma: 5 people, 33.33%

* Approximation only. Some reports may have incomplete information.

Do you take Mytesi and Profen?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Mytesi and Profen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Mytesi:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Profen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Mytesi and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Profen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on crofelemer and ibuprofen (the active ingredients of Mytesi and Profen, respectively), and Mytesi and Profen (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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