Diphen and Anzemet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Anzemet (dolasetron mesylate). Common drug interactions include neuropathy peripheral among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Anzemet. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Anzemet?

Anzemet has active ingredients of dolasetron mesylate. eHealthMe is studying from 2,603 Anzemet users. Check the latest studies of Anzemet.

On Jul, 15, 2026

65 people who take Diphen and Anzemet together, and have interactions are studied.

What are the common drug interactions of Diphen and Anzemet, by gender? *:

female:

Neuropathy peripheral (surface nerve damage)
Pyrexia (fever)
Stomatitis (inflammation of mucous membrane of mouth)
Bone disorder
Fatigue (feeling of tiredness)
Neck pain
Rectal haemorrhage (bleeding from anus)
Urinary tract infection
Weight decreased
Chest pain

male:

Death
Dyspnoea (difficult or laboured respiration)
Hydronephrosis (water inside the kidney)
Pain
Pneumonia
Thrombocytopenia (decrease of platelets in blood)
Weakness
Acne (skin problems that cause pimples)
Apnoea (suspension of external breathing)
Blood creatinine increased

What are the common drug interactions of Diphen and Anzemet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dyspnoea (difficult or laboured respiration)
Haemoglobin decreased
Hypotension (abnormally low blood pressure)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Abdominal pain upper
Anoxia (low oxygen)
Apnoea (suspension of external breathing)
Arrhythmia (irregular heartbeat)
Caecitis (inflammation of the cecum)
Chest discomfort

40-49:

Anaemia (lack of blood)
Pain
Fatigue (feeling of tiredness)
Back pain
Bone disorder
Impaired healing
Injury
Neuropathy peripheral (surface nerve damage)
Rectal haemorrhage (bleeding from anus)
Urinary tract infection

50-59:

Dysarthria (speech disorder)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Electrocardiogram qt corrected interval prolonged
Electrocardiogram qt prolonged
Epistaxis (bleed from the nose)
Erythema (redness of the skin)
Eye disorder
Febrile neutropenia (fever with reduced white blood cells)
Haematocrit decreased
Haemoglobin decreased

60+:

Dyspnoea (difficult or laboured respiration)
Febrile neutropenia (fever with reduced white blood cells)
Bradycardia (abnormally slow heart action)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Coma (state of unconsciousness lasting more than six hours)
Cryptogenic organizing pneumonia (small airways (bronchioles) and air exchange sac (alveoli) become inflamed with connective tissue)
Enterococcal bacteraemia (presence of bacteria lactic acid in the blood)
Neutropenic infection (infection with less neutrophil numbers in blood)
Oedema lower limb (fluid collection in tissue of lower leg)
Stomatitis (inflammation of mucous membrane of mouth)

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 7 people, 10.77%
Nausea (feeling of having an urge to vomit): 6 people, 9.23%
Lung Neoplasm Malignant (cancer tumour of lung): 5 people, 7.69%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 5 people, 7.69%
Lung Cancer - Non-Small Cell (lung cancer): 4 people, 6.15%
Immunodeficiency Common Variable: 4 people, 6.15%
Breast Cancer Metastatic: 4 people, 6.15%
Breast Cancer: 4 people, 6.15%

* Approximation only. Some reports may have incomplete information.

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