Diphen and Busulfex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Busulfex (busulfan). Common drug interactions include aplastic anaemia among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Busulfex. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Busulfex?

Busulfex has active ingredients of busulfan. eHealthMe is studying from 3,408 Busulfex users. Check the latest studies of Busulfex.

On Jul, 12, 2026

27 people who take Diphen and Busulfex together, and have interactions are studied.

What are the common drug interactions of Diphen and Busulfex, by gender? *:

female:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Sepsis (a severe blood infection that can lead to organ failure and death)
Adenovirus infection
Epistaxis (bleed from the nose)
Hypotension (abnormally low blood pressure)
Platelet count decreased
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Ascites (accumulation of fluid in the abdominal cavity)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cerebral infarction (less blood supply to brain resulting tissue damage)

male:

Febrile neutropenia (fever with reduced white blood cells)
Hypotension (abnormally low blood pressure)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hepatomegaly (abnormal enlargement of the liver)
Mucosal inflammation (infection of mucous membrane)
Pseudomonal sepsis (pseudomonas infections are diseases caused by a bacterium from the genus pseudomonas)
Respiratory distress (difficulty in breathing)
Coma (state of unconsciousness lasting more than six hours)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

What are the common drug interactions of Diphen and Busulfex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Brain death
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Febrile neutropenia (fever with reduced white blood cells)
Hallucination (an experience involving the perception of something not present)
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)
Intentional self-injury

10-19:

Drug administration error
Febrile neutropenia (fever with reduced white blood cells)
Staphylococcal infection (an infection with staphylococcus bacteria)

20-29:

Adenovirus infection
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Febrile neutropenia (fever with reduced white blood cells)

30-39:

Sepsis (a severe blood infection that can lead to organ failure and death)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Malignant melanoma (skin cancer rises from melancytes)
Epistaxis (bleed from the nose)
Hypotension (abnormally low blood pressure)
Platelet count decreased

40-49:

n/a

50-59:

n/a

60+:

Coma (state of unconsciousness lasting more than six hours)
Hallucination (an experience involving the perception of something not present)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Oculogyric crisis (a spasmodic movement of the eyeballs into a fixed position due to medicine reaction)
Respiratory depression (respiration has a rate below 12 breaths)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)

What are the existing conditions these people have? *

Bone Marrow Conditioning Regimen: 5 people, 18.52%
Nausea (feeling of having an urge to vomit): 4 people, 14.81%
Pain: 3 people, 11.11%
Haematopoietic Stem Cell Mobilisation: 3 people, 11.11%
Iron Overload: 2 people, 7.41%
Constipation: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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