Diphen and Camptosar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Camptosar (irinotecan hydrochloride). Common drug interactions include intervertebral disc degeneration among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Camptosar. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Camptosar?

Camptosar has active ingredients of irinotecan hydrochloride. eHealthMe is studying from 7,145 Camptosar users. Check the latest studies of Camptosar.

On Jul, 11, 2026

43 people who take Diphen and Camptosar together, and have interactions are studied.

What are the common drug interactions of Diphen and Camptosar, by gender? *:

female:

Intervertebral disc degeneration (spinal disc degeneration)
Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Muscle twitching
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neurological decompensation (inability of brain to maintain proper function)
Oedema (fluid collection in tissue)
Oral candidiasis (fungal infection of mouth)
Oropharyngeal pain
Osteosclerosis (an elevation in bone density)

male:

Death
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Weight decreased
Cough
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Hypotension (abnormally low blood pressure)
Interstitial lung disease
Renal failure (kidney dysfunction)
Venous thrombosis deep limb (blood clot that forms in a vein deep in the limb)
Abdominal discomfort

What are the common drug interactions of Diphen and Camptosar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Neutropenia (an abnormally low number of neutrophils)
Stomatitis (inflammation of mucous membrane of mouth)
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Platelet count decreased
Abdominal pain
Constipation
Dry mouth
Dysuria (painful or difficult urination)
Feeding disorder (when children refuse to eat certain food groups)
Hypophagia (reduced food intake)

20-29:

n/a

30-39:

Infusion related reaction
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Brain neoplasm (tumour of brain)
Confusional state
Constipation
Death
Dizziness
Dysphonia (speech disorder attributable to a disorder of phonation)
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)

40-49:

Chest pain
Hypotension (abnormally low blood pressure)
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues)
Muscle spasms (muscle contraction)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

Sleep disorder
Tremor (trembling or shaking movements in one or more parts of your body)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemolytic uraemic syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more)
Microangiopathic haemolytic anaemia (anaemia due to inability of bone marrow to compensate the premature destruction of red blood cells)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Renal failure acute (rapid kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Cough

60+:

Weight decreased
Asthenia (weakness)
Exostosis (formation of new bone on the surface of a bone)
Glioblastoma multiforme (most common and deadliest of malignant primary brain tumours in adults)
Hypoaesthesia (reduced sense of touch or sensation)
Impaired healing
Intervertebral disc degeneration (spinal disc degeneration)
Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

What are the existing conditions these people have? *

Rectal Cancer (cancer of rectum): 10 people, 23.26%
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 6 people, 13.95%
Colon Cancer: 5 people, 11.63%
Brain Neoplasm Malignant (brain cancer tumour): 4 people, 9.30%
Nausea (feeling of having an urge to vomit): 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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