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Folate and Naltrexone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Folate (folic acid) and Naltrexone (naltrexone). Common drug interactions include fatigue among females and aggression among males.

The phase IV clinical study analyzes what interactions people have when they take Folate and Naltrexone. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Folate?

Folate has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 6,546 Folate users. Check the latest studies of Folate.

What is Naltrexone?

Naltrexone has active ingredients of naltrexone. eHealthMe is studying from 4,833 Naltrexone users. Check the latest studies of Naltrexone.

On Jul, 11, 2026

22 people who take Folate and Naltrexone together, and have interactions are studied.

Folate and Naltrexone drug interactions.

What are the common drug interactions of Folate and Naltrexone, by gender? *:

female:

  1. Fatigue (feeling of tiredness)
  2. Accident at home
  3. Eye swelling
  4. Foot fracture
  5. Immune system disorder
  6. Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))
  7. Oral infection
  8. Oropharyngeal pain
  9. Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
  10. Skin mass

male:

  1. Aggression
  2. Depressed mood
  3. Injection site reaction
  4. Irritability
  5. Mood altered (changes in mood)
  6. Suicidal ideation
  7. Urinary tract infection
  8. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  9. Anger
  10. Blood glucose decreased

What are the common drug interactions of Folate and Naltrexone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Aggression
  2. Depressed mood
  3. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  4. Anger
  5. Hyperacusis (disorder in loudness perception)
  6. Irritability
  7. Mood altered (changes in mood)

20-29:

n/a

30-39:

  1. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  2. Inflammatory bowel disease
  3. Dry mouth
  4. Back pain
  5. Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
  6. Depressed mood
  7. Dysphagia (a condition in which swallowing is difficult or painful)
  8. Fatigue (feeling of tiredness)
  9. Infection
  10. Infusion related reaction

40-49:

  1. Depression
  2. Diarrhoea
  3. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  4. Injection site abscess
  5. Injection site cellulitis (injection site inflammation)
  6. Injection site reaction
  7. Insomnia (sleeplessness)
  8. Mood altered (changes in mood)
  9. Suicidal ideation
  10. Urinary tract infection

50-59:

  1. Asthenia (weakness)
  2. Blood glucose decreased
  3. Chest discomfort
  4. Fatigue (feeling of tiredness)
  5. Headache (pain in head)
  6. Iodine deficiency
  7. Nausea (feeling of having an urge to vomit)
  8. Throat tightness
  9. Tremor (trembling or shaking movements in one or more parts of your body)
  10. Vomiting

60+:

  1. Accident at home
  2. Eye swelling
  3. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  4. Hallucination (an experience involving the perception of something not present)
  5. Osteochondrosis (a family of orthopaedic diseases of the joint that occur in children and adolescents)
  6. Depression
  7. Diarrhoea
  8. Fall
  9. Feeling of despair
  10. Fungal infection

What are the existing conditions these people have? *

  1. Primary Immunodeficiency Syndrome: 3 people, 13.64%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 13.64%
  3. Immunodeficiency Common Variable: 3 people, 13.64%
  4. Pain: 2 people, 9.09%
  5. Indigestion: 2 people, 9.09%
  6. Fatigue (feeling of tiredness): 2 people, 9.09%
  7. Drowsiness: 2 people, 9.09%
  8. Cystic Fibrosis (disease of the secretary glands): 2 people, 9.09%
  9. Cushing's Syndrome (obesity, a rounded face, increased fat): 2 people, 9.09%
  10. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Folate and Naltrexone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Folate and Naltrexone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Folate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Naltrexone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Folate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Naltrexone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on folic acid and naltrexone (the active ingredients of Folate and Naltrexone, respectively), and Folate and Naltrexone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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